The HSP90 family: structure, regulation, function, and implications in health and disease
A Hoter, ME El-Sabban, HY Naim - International journal of molecular …, 2018 - mdpi.com
The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are
involved in myriad cellular processes. Their distribution in various cellular compartments …
involved in myriad cellular processes. Their distribution in various cellular compartments …
Heat shock proteins and cancer
J Wu, T Liu, Z Rios, Q Mei, X Lin, S Cao - Trends in pharmacological …, 2017 - cell.com
Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding
and maturation whose expression is induced by heat shock or other stressors. The major …
and maturation whose expression is induced by heat shock or other stressors. The major …
Targeting heat shock proteins in cancer: a promising therapeutic approach
S Chatterjee, TF Burns - International journal of molecular sciences, 2017 - mdpi.com
Heat shock proteins (HSPs) are a large family of chaperones that are involved in protein
folding and maturation of a variety of “client” proteins protecting them from degradation …
folding and maturation of a variety of “client” proteins protecting them from degradation …
Heat shock proteins: agents of cancer development and therapeutic targets in anti-cancer therapy
CW Yun, HJ Kim, JH Lim, SH Lee - Cells, 2019 - mdpi.com
Heat shock proteins (HSPs) constitute a large family of molecular chaperones classified by
their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90 …
their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90 …
Mammalian heat shock response and mechanisms underlying its genome-wide transcriptional regulation
The heat shock response (HSR) is critical for survival of all organisms. However, its scope,
extent, and the molecular mechanism of regulation are poorly understood. Here we show …
extent, and the molecular mechanism of regulation are poorly understood. Here we show …
HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma
X Xiao, W Wang, Y Li, D Yang, X Li, C Shen… - Journal of Experimental …, 2018 - Springer
Background Osteosarcoma is the most common primary bone tumor in children and
adolescents. Unfortunately, osteosarcoma treatments often fail due to the development of …
adolescents. Unfortunately, osteosarcoma treatments often fail due to the development of …
The HSP70 chaperone machinery: J proteins as drivers of functional specificity
HH Kampinga, EA Craig - Nature reviews Molecular cell biology, 2010 - nature.com
Heat shock 70 kDa proteins (HSP70s) are ubiquitous molecular chaperones that function in
a myriad of biological processes, modulating polypeptide folding, degradation and …
a myriad of biological processes, modulating polypeptide folding, degradation and …
Whole genome analysis of a schistosomiasis-transmitting freshwater snail
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma
mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global …
mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global …
Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease
BS Rutledge, WY Choy, ML Duennwald - Journal of Biological Chemistry, 2022 - ASBMB
The toxic accumulation of misfolded proteins as inclusions, fibrils, or aggregates is a
hallmark of many neurodegenerative diseases. However, how molecular chaperones, such …
hallmark of many neurodegenerative diseases. However, how molecular chaperones, such …
Heat shock proteins and HSF1 in cancer
AM Cyran, A Zhitkovich - Frontiers in oncology, 2022 - frontiersin.org
Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …
activities of protein chaperones and proteolytic machinery. Upon encountering protein …