An SR protein is essential for activating DNA repair in malaria parasites
Plasmodium falciparum, the parasite responsible for the deadliest form of human malaria,
replicates within the erythrocytes of its host, where it encounters numerous pressures that …
replicates within the erythrocytes of its host, where it encounters numerous pressures that …
Phosphorylation of the canonical histone H2A marks foci of damaged DNA in malaria parasites
M Goyal, A Heinberg, V Mitesser, S Kandelis-Shalev… - Msphere, 2021 - Am Soc Microbiol
Plasmodium falciparum parasites proliferate within circulating red blood cells and are
responsible for the deadliest form of human malaria. These parasites are exposed to …
responsible for the deadliest form of human malaria. These parasites are exposed to …
Plasmodium Ape1 is a multifunctional enzyme in mitochondrial base excision repair and is required for efficient transition from liver to blood stage infection
The malaria parasite has a single mitochondrion which carries multiple tandem repeats of its
6 kb genome encoding three proteins of the electron transport chain. There is little …
6 kb genome encoding three proteins of the electron transport chain. There is little …
DNA damage response pathways in dinoflagellates
C Li, JTY Wong - Microorganisms, 2019 - mdpi.com
Dinoflagellates are a general group of phytoplankton, ubiquitous in aquatic environments.
Most dinoflagellates are non-obligate autotrophs, subjected to potential physical and …
Most dinoflagellates are non-obligate autotrophs, subjected to potential physical and …
Plasmodium falciparum Apn1 homolog is a mitochondrial base excision repair protein with restricted enzymatic functions
The malaria parasite carries two organelles, the apicoplast and mitochondrion, whose DNA
genomes must be maintained for optimal function and parasite survival under genotoxic …
genomes must be maintained for optimal function and parasite survival under genotoxic …
[HTML][HTML] Analysis of methyltransferase (MTase) domain from Zika virus (ZIKV)
S Afaq, A Atiya, A Malik, AS Alwabli, DA Alzahrani… - …, 2020 - ncbi.nlm.nih.gov
A comprehensive analysis of methyltransferase (MTase) from Zika virus (ZIKV) is of interest
in the development of drugs and biomarkers in the combat and care of ZIKA fever with …
in the development of drugs and biomarkers in the combat and care of ZIKA fever with …
[HTML][HTML] Molecular docking based design of Dengue NS5 methyltransferase inhibitors
Dengue is a viral infection caused by RNA infection of the family Flaviviridae and spread by
the Aedes mosquitoes. Dengue NS5 methyltransferase is a known drug target for the …
the Aedes mosquitoes. Dengue NS5 methyltransferase is a known drug target for the …
Synergistic action between PfHsp90 inhibitor and PfRad51 inhibitor induces elevated DNA damage sensitivity in the malaria parasite
W Tabassum, P Singh, N Suthram… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
The DNA recombinase Rad51 from the human malaria parasite Plasmodium falciparum has
emerged as a potential drug target due to its central role in the homologous recombination …
emerged as a potential drug target due to its central role in the homologous recombination …
[HTML][HTML] From sequence analysis of DPP-4 to molecular docking based searching of its inhibitors
AS Alsamghan, AS Alwabli, M Abadi, SA Alsaleem… - …, 2020 - ncbi.nlm.nih.gov
Literature data suggests that Dipeptidyl peptidase-4 (DPP-4) is a potential target for type 2
Diabetes Mellitus. Therefore, it is of interest to identify new DPP-4 inhibitors using molecular …
Diabetes Mellitus. Therefore, it is of interest to identify new DPP-4 inhibitors using molecular …
[HTML][HTML] Networking of predicted post-translational modification (PTM) sites in human EGFR
A Malik, S Afaq, AS Alwabli, K Al-Ghmady - Bioinformation, 2019 - ncbi.nlm.nih.gov
Epidermal growth factor receptor (EGFR) binds to EGF activating tyrosine phosphorylation
through receptor dimerization prompting uncontrolled multiplication. Domain organization …
through receptor dimerization prompting uncontrolled multiplication. Domain organization …