Retinal biomarkers in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis

YJ Ge, W Xu, YN Ou, Y Qu, YH Ma, YY Huang… - Ageing Research …, 2021 - Elsevier
Background Retinal changes may reflect the pathophysiological processes in the central
nervous system and can be assessed by imaging modalities non-invasively. We aim to …

Retinal vasculopathy in Alzheimer's disease

H Shi, Y Koronyo, A Rentsendorj, DT Fuchs… - Frontiers in …, 2021 - frontiersin.org
The retina has been increasingly investigated as a site of Alzheimer's disease (AD)
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …

Retinal pathological features and proteome signatures of Alzheimer's disease

Y Koronyo, A Rentsendorj, N Mirzaei, GC Regis… - Acta …, 2023 - Springer
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …

[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in Retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

Müller cell degeneration and microglial dysfunction in the Alzheimer's retina

QA Xu, P Boerkoel, V Hirsch-Reinshagen… - Acta Neuropathologica …, 2022 - Springer
Amyloid beta (Aβ) deposits in the retina of the Alzheimer's disease (AD) eye may provide a
useful diagnostic biomarker for AD. This study focused on the relationship of Aβ with …

Role of retinal amyloid-β in neurodegenerative diseases: overlapping mechanisms and emerging clinical applications

L Wang, X Mao - International journal of molecular sciences, 2021 - mdpi.com
Amyloid-β (Aβ) accumulations have been identified in the retina for neurodegeneration-
associated disorders like Alzheimer's disease (AD), glaucoma, and age-related macular …

Advancements in materials, devices, and integration schemes for a new generation of neuromorphic computers

S Najmaei, AL Glasmann, MA Schroeder, WL Sarney… - Materials Today, 2022 - Elsevier
The slowing pace of performance improvements in modern processors along with the
breakdown of power scaling forecasts an imminent end to the traditional transistor scaling …

Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review

A Wolf, K Tripanpitak, S Umeda… - Frontiers in …, 2023 - frontiersin.org
Mild cognitive impairment (MCI), representing the 'transitional zone'between normal
cognition and dementia, has become a novel topic in clinical research. Although early …

Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer's disease

H Shi, Y Koronyo, DT Fuchs, J Sheyn… - Acta Neuropathologica …, 2020 - Springer
Extensive effort has been made studying retinal pathology in Alzheimer's disease (AD) to
improve early noninvasive diagnosis and treatment. Particularly relevant are vascular …

Oxidative stress in the brain and retina after traumatic injury

AK Ryan, W Rich, MA Reilly - Frontiers in neuroscience, 2023 - frontiersin.org
The brain and the retina share many physiological similarities, which allows the retina to
serve as a model of CNS disease and disorder. In instances of trauma, the eye can even …