The evolution of fungicide resistance

JA Lucas, NJ Hawkins, BA Fraaije - Advances in applied microbiology, 2015 - Elsevier
Fungicides are widely used in developed agricultural systems to control disease and
safeguard crop yield and quality. Over time, however, resistance to many of the most …

Azole fungicides–understanding resistance mechanisms in agricultural fungal pathogens

CL Price, JE Parker, AGS Warrilow… - Pest management …, 2015 - Wiley Online Library
Plant fungal pathogens can have devastating effects on a wide range of crops, including
cereals and fruit (such as wheat and grapes), causing losses in crop yield, which are costly …

[HTML][HTML] Exploring the genomic diversity of black yeasts and relatives (Chaetothyriales, Ascomycota)

MM Teixeira, LF Moreno, BJ Stielow, A Muszewska… - Studies in mycology, 2017 - Elsevier
Abstract The order Chaetothyriales (Pezizomycotina, Ascomycetes) harbours obligatorily
melanised fungi and includes numerous etiologic agents of chromoblastomycosis …

Update on mechanisms of azole resistance in Mycosphaerella graminicola and implications for future control

HJ Cools, BA Fraaije - Pest management science, 2013 - Wiley Online Library
This review summarises recent investigations into the molecular mechanisms responsible
for the decline in sensitivity to azole (imidazole and triazole) fungicides in European …

Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens

R Becher, SGR Wirsel - Applied microbiology and biotechnology, 2012 - Springer
Azoles have been applied widely to combat pathogenic fungi in medicine and agriculture
and, consequently, loss of efficacy has occurred in populations of some species. Often, but …

Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?

SL Kelly, DE Kelly - … Transactions of the Royal Society B …, 2013 - royalsocietypublishing.org
The first eukaryote genome revealed three yeast cytochromes P450 (CYPs), hence the
subsequent realization that some microbial fungal genomes encode these proteins in 1 per …

Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator

L Jones, S Riaz, A Morales-Cruz, KCH Amrine… - BMC genomics, 2014 - Springer
Background Powdery mildew, caused by the obligate biotrophic fungus Erysiphe necator, is
an economically important disease of grapevines worldwide. Large quantities of fungicides …

The Multi-Fungicide Resistance Status of Aspergillus fumigatus Populations in Arable Soils and the Wider European Environment

B Fraaije, S Atkins, S Hanley, A Macdonald… - Frontiers in …, 2020 - frontiersin.org
The evolution and spread of pan-azole resistance alleles in clinical and environmental
isolates of Aspergillus fumigatus is a global human health concern. The identification of …

Resistance to antifungals that target CYP51

JE Parker, AGS Warrilow, CL Price, JGL Mullins… - Journal of Chemical …, 2014 - Springer
Fungal diseases are an increasing global burden. Fungi are now recognised to kill more
people annually than malaria, whilst in agriculture, fungi threaten crop yields and food …

Overexpression of the sterol 14α‐demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype

HJ Cools, C Bayon, S Atkins, JA Lucas… - Pest management …, 2012 - Wiley Online Library
BACKGROUND: The recent evolution towards resistance to azole fungicides in European
populations of the wheat pathogen Mycosphaerella graminicola has been caused by the …