[HTML][HTML] A case report of acute hypothermia during initial inpatient clozapine titration with review of current literature on clozapine-induced temperature dysregulations
BG Burk, AH Ward, B Clark - BMC psychiatry, 2020 - Springer
Background Here we describe a unique case of clozapine-associated hypothermia during
initial titration of this medication in an acute inpatient psychiatry setting. Only a handful of …
initial titration of this medication in an acute inpatient psychiatry setting. Only a handful of …
[HTML][HTML] Searching for multi-target antipsychotics: discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors
G Neves, R Menegatti, CB Antonio… - Bioorganic & medicinal …, 2010 - Elsevier
We described herein the design, synthesis, and pharmacological evaluation of N-
phenylpiperazine heterocyclic derivatives as multi-target compounds potentially useful for …
phenylpiperazine heterocyclic derivatives as multi-target compounds potentially useful for …
Antipsychotic inductors of brain hypothermia and torpor-like states: perspectives of application
YS Tarahovsky, IS Fadeeva, NP Komelina… - …, 2017 - Springer
Hypothermia and hypometabolism (hypometabothermia) normally observed during natural
hibernation and torpor, allow animals to protect their body and brain against the damaging …
hibernation and torpor, allow animals to protect their body and brain against the damaging …
An assessment of the permeation enhancer, 1-phenyl-piperazine (PPZ), on paracellular flux across rat intestinal mucosae in Ussing chambers
VA Bzik, DJ Brayden - Pharmaceutical research, 2016 - Springer
ABSTRACT Purpose 1-phenyl piperazine (PPZ) emerged from a Caco-2 monolayer screen
as having high enhancement potential due to a capacity to increase permeation without …
as having high enhancement potential due to a capacity to increase permeation without …
Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579
TET Pompeu, FRS Alves, CDM Figueiredo… - European Journal of …, 2013 - Elsevier
In an attempt to increase the affinity of our antipsychotic lead compound LASSBio-579 (1-((1-
(4-chlorophenyl)-1H-pyrazol-4-yl) methyl)-4-phenylpiperazine;(2)) for the 5-HT 2A receptor …
(4-chlorophenyl)-1H-pyrazol-4-yl) methyl)-4-phenylpiperazine;(2)) for the 5-HT 2A receptor …
New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia
Previous behavioral and receptor binding studies on N-phenylpiperazine derivatives by our
group indicated that LASSBio-579, LASSBio-580 and LASSBio-581 could be potential …
group indicated that LASSBio-579, LASSBio-580 and LASSBio-581 could be potential …
Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters
JDA Olivier, AR Cools, PMT Deen, B Olivier… - European journal of …, 2010 - Elsevier
To investigate whether life-long disturbed serotonin neurotransmission may result in
adaptive changes of dopaminergic and noradrenergic systems, effects of drugs on stress …
adaptive changes of dopaminergic and noradrenergic systems, effects of drugs on stress …
Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound
TF Gomes, TET Pompeu, DA Rodrigues, F Noël… - European Journal of …, 2013 - Elsevier
Using a combination of docking and molecular dynamics simulations, we predicted that p-
hydroxylation by CYP1A2 would be the main metabolic pathway for the 1-[1-(4 …
hydroxylation by CYP1A2 would be the main metabolic pathway for the 1-[1-(4 …
Severe recurrent hypothermia in an elderly patient with refractory mania associated with atypical antipsychotic, valproic acid and oxcarbazepine therapy
OO Ajayi, S Holroyd - Case Reports, 2017 - casereports.bmj.com
Hypothermia is a rare but serious condition that has been associated with various
psychiatric medications. We present a 76-year-old woman with refractory mania who …
psychiatric medications. We present a 76-year-old woman with refractory mania who …
LASSBio-579, a prototype antipsychotic drug, and clozapine are effective in novel object recognition task, a recognition memory model
CB Antonio, AH Betti, V Herzfeldt… - Behavioural …, 2016 - journals.lww.com
Previous studies on the N-phenylpiperazine derivative LASSBio-579 have suggested that
LASSBio-579 has an atypical antipsychotic profile. It binds to D 2, D 4 and 5-HT 1A …
LASSBio-579 has an atypical antipsychotic profile. It binds to D 2, D 4 and 5-HT 1A …