Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during
embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and …

Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …

Haematopoietic stem cells (HSCs) are derived early from embryonic precursors, such as
haemogenic endothelial cells and pre-haematopoietic stem cells (pre-HSCs), the molecular …

The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells
(hPSCs) will depend on the accurate recapitulation of embryonic haematopoiesis. In the …

Megakaryocytes (MKs) are responsible for platelet biogenesis, which is believed to occur
canonically in adult bone marrow (BM) and in the fetal liver during development. However …

Hematopoiesis is the process by which both fetal and adult organisms derive the full
repertoire of blood cells from a single multipotent progenitor cell type, the hematopoietic …

Hematopoietic stem cells (HSCs) first emerge in the embryonic aorta-gonad-mesonephros
(AGM) region. Studies of model organisms defined intersecting signaling pathways that …

Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …

Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in
vitro differentiation models that will transform our approach to the study of human …

Haematopoietic stem cells (HSCs) are generated from haemogenic endothelial (HE) cells
via the formation of intra-aortic haematopoietic clusters (IAHCs) in vertebrate embryos. The …