A brief introduction to chemical reaction optimization

CJ Taylor, A Pomberger, KC Felton, R Grainger… - Chemical …, 2023 - ACS Publications
From the start of a synthetic chemist's training, experiments are conducted based on recipes
from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist …

A field guide to flow chemistry for synthetic organic chemists

L Capaldo, Z Wen, T Noël - Chemical science, 2023 - pubs.rsc.org
Flow chemistry has unlocked a world of possibilities for the synthetic community, but the idea
that it is a mysterious “black box” needs to go. In this review, we show that several of the …

Automated solution-phase multiplicative synthesis of complex glycans up to a 1,080-mer

W Yao, DC Xiong, Y Yang, C Geng, Z Cong, F Li… - Nature …, 2022 - nature.com
Carbohydrates play essential roles in nature, such as in cell–cell communication, cell growth
and immunoresponse. However, the synthesis of structurally well-defined carbohydrates …

[HTML][HTML] Scope of machine learning in materials research—A review

MH Mobarak, MA Mimona, MA Islam, N Hossain… - Applied Surface Science …, 2023 - Elsevier
This comprehensive review investigates the multifaceted applications of machine learning in
materials research across six key dimensions, redefining the field's boundaries. It explains …

Applications of Transmission Electron Microscopy in Phase Engineering of Nanomaterials

G Li, H Zhang, Y Han - Chemical Reviews, 2023 - ACS Publications
Phase engineering of nanomaterials (PEN) is an emerging field that aims to tailor the
physicochemical properties of nanomaterials by precisely manipulating their crystal phases …

Evolving scenario of big data and Artificial Intelligence (AI) in drug discovery

MK Tripathi, A Nath, TP Singh, AS Ethayathulla… - Molecular Diversity, 2021 - Springer
The accumulation of massive data in the plethora of Cheminformatics databases has made
the role of big data and artificial intelligence (AI) indispensable in drug design. This has …

Analytical tools integrated in continuous-flow reactors: which one for what?

M Rodriguez-Zubiri, FX Felpin - Organic Process Research & …, 2022 - ACS Publications
The concept and practices of chemical synthesis are being profoundly transformed toward
the development of fully autonomous continuous processes. Critical to the development of …

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

CR Sagandira, S Nqeketo, K Mhlana, T Sonti… - Reaction Chemistry & …, 2022 - pubs.rsc.org
Continuous flow chemistry has opened a new paradigm in both the laboratory and
pharmaceutical industry. This review details the recently reported literature on continuous …

Will the next generation of chemical plants be in miniaturized flow reactors?

JCM Monbaliu, J Legros - Lab on a Chip, 2023 - pubs.rsc.org
For decades, a production paradigm based on centralized, stepwise, large scale processes
has dominated the chemical industry horizon. While effective to meet an ever increasing …

Forgotten and forbidden chemical reactions revitalised through continuous flow technology

A Bonner, A Loftus, AC Padgham… - Organic & Biomolecular …, 2021 - pubs.rsc.org
Continuous flow technology has played an undeniable role in enabling modern chemical
synthesis, whereby a myriad of reactions can now be performed with greater efficiency …