Before, during, and after: An Argument for Safety and Improved Outcome of Thrombolysis in Acute Ischemic Stroke with Direct Oral Anticoagulant Treatment

S Monjazeb, HV Chang, PD Lyden - Annals of Neurology, 2024 - Wiley Online Library
Direct oral anticoagulants are the primary stroke prevention option in patients with atrial
fibrillation. Anticoagulant use before stroke, however, might inhibit clinician comfort with …

[HTML][HTML] APMCG-1 attenuates ischemic stroke injury by reducing oxidative stress and apoptosis and promoting angiogenesis via activating PI3K/AKT pathway

X He, M Wu, L Chen, M Liu, X Hu, Y Meng… - Biomedicine & …, 2024 - Elsevier
Ischemic stroke (IS) is a major cause of mortality and morbidity worldwide. Beyond
thrombolysis, strategies targeting anti-oxidative apoptosis and angiogenesis are considered …

Idarucizumab in dabigatran-treated patients with acute stroke: a review and clinical update

S Frol, J Pretnar Oblak, M Šabovič, G Ntaios… - Frontiers in …, 2024 - frontiersin.org
Idarucizumab is an antibody fragment specific for the immediate reversal of dabigatran
anticoagulation effects. The use of idarucizumab is approved for dabigatran-treated patients …

Higher efficacy of intravenous thrombolysis in patients with acute ischemic stroke taking direct oral anticoagulants—A new relevant hypothesis

S Frol, J Pretnar Oblak, P Kermer, G Ntaios… - Frontiers in …, 2024 - frontiersin.org
Introduction Direct oral anticoagulants (DOACs) have been established as first-line therapy
for stroke prevention in patients with non-valvular atrial fibrillation due to their high safety …

Thrombolysis After Dabigatran Reversal for Acute Ischemic Stroke: A National Registry-Based Study and Meta-Analysis

A Theodorou, K Melanis, E Bakola, M Chondrogianni… - Neurology, 2024 - neurology.org
Background and Objectives Limited data exist on the safety of IV thrombolysis (IVT) for acute
ischemic stroke (AIS) after dabigatran reversal with idarucizumab. We sought to evaluate the …

Hemorrhagic complications after stroke treatment with intravenous thrombolysis despite use of direct oral anticoagulants: an observational study

A Kleeberg, PA Ringleb, I Huber… - Therapeutic …, 2024 - journals.sagepub.com
Background: For patients experiencing ischemic stroke despite receiving therapy with direct
oral anticoagulants (DOAC) and without endovascular treatment options, therapeutic …

Detection of factor Xa activity using giant magnetoresistive biosensors

Y Lee, S Kim, TJ Song, SX Wang, JR Lee - Analytica Chimica Acta, 2024 - Elsevier
Background As anticoagulants are widely used to treat patients with atrial fibrillation (AF)
and other thrombotic conditions, it is necessary for physicians to determine whether the …

[HTML][HTML] Thrombolysis for Ischemic Stroke Despite Recent Ingestion of Direct Oral Anticoagulants–A Growing Dilemma Also in India

TR Meinel, NK Paramasivan, BK Menon… - Annals of Indian …, 2024 - journals.lww.com
The administration of intravenous thrombolysis (IVT) for patients with acute ischemic stroke
who have recently ingested direct oral anticoagulants (DOACs) presents a clinical challenge …

Cerebrolysin, Hemorrhagic Transformation, and Anticoagulation Timing after Reperfusion Therapy in Stroke: Secondary Analysis of the CEREHETIS Trial

MN Kalinin, DR Khasanova - 2024 - researchsquare.com
Background Evidence supports Cerebrolysin's efficacy in reducing hemorrhagic
transformation (HT), but its impact on the timing of resuming anticoagulation therapy in …