Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications
The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …
highest level cognitive and emotional processes. Its local circuits among glutamatergic …
Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents
R Jabarin, S Netser, S Wagner - Molecular Autism, 2022 - Springer
Main In recent years, substantial advances in social neuroscience have been realized,
including the generation of numerous rodent models of autism spectrum disorder. Still, it can …
including the generation of numerous rodent models of autism spectrum disorder. Still, it can …
mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity
Postmortem studies have revealed increased density of excitatory synapses in the brains of
individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR …
individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR …
Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring
F Mirabella, G Desiato, S Mancinelli, G Fossati… - Immunity, 2021 - cell.com
Early prenatal inflammatory conditions are thought to be a risk factor for different
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy …
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy …
Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex
While shaped and constrained by axonal connections, fMRI-based functional connectivity
reorganizes in response to varying interareal input or pathological perturbations. However …
reorganizes in response to varying interareal input or pathological perturbations. However …
Infraslow state fluctuations govern spontaneous fMRI network dynamics
Spontaneous brain activity as assessed with resting-state fMRI exhibits rich spatiotemporal
structure. However, the principles by which brain-wide patterns of spontaneous fMRI activity …
structure. However, the principles by which brain-wide patterns of spontaneous fMRI activity …
Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications
JP Delling, TM Boeckers - Journal of Neurodevelopmental Disorders, 2021 - Springer
Background Autism spectrum disorder (ASD) is a neurodevelopmental condition, which is
characterized by clinical heterogeneity and high heritability. Core symptoms of ASD include …
characterized by clinical heterogeneity and high heritability. Core symptoms of ASD include …
Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes
Abstract Autism Spectrum Disorder (ASD) is characterized by substantial, yet highly
heterogeneous abnormalities in functional brain connectivity. However, the origin and …
heterogeneous abnormalities in functional brain connectivity. However, the origin and …
Differences in subcortico-cortical interactions identified from connectome and microcircuit models in autism
The pathophysiology of autism has been suggested to involve a combination of both
macroscale connectome miswiring and microcircuit anomalies. Here, we combine …
macroscale connectome miswiring and microcircuit anomalies. Here, we combine …
Network structure of the mouse brain connectome with voxel resolution
Fine-grained descriptions of brain connectivity are required to understand how neural
information is processed and relayed across spatial scales. Previous investigations of the …
information is processed and relayed across spatial scales. Previous investigations of the …