Together, histone acetyltransferases and histone deacetylases (HDACs) determine the
acetylation status of histones. This acetylation affects the regulation of gene expression, and …

Core-binding factors (CBFs) are a class of haematopoietic transcription factors that are
crucial for the regulation of haematopoietic ontogeny, and are frequent targets of mutation …

Diffuse large B-cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is
curable in less than 50% of patients. Prognostic models based on pre-treatment …

Acute leukaemias are characterized by recurring chromosomal aberrations and gene
mutations that are crucial to disease pathogenesis. It is now evident that epigenetic …

Abstract Effects of the histone deacetylase (HDAC) inhibitor MS-275 have been examined in
human leukemia and lymphoma cells (U937, HL-60, K562, and Jurkat) as well as in primary …

Angiogenesis is a complex biological process involving the coordinated modulation of many
genes. Histone deacetylases (HDAC) are a growing family of enzymes that mediate the …

Myeloid malignancies are clonal disorders that are characterized by acquired somatic
mutation in hematopoietic progenitors. Recent advances in our understanding of the genetic …

Histone acetylation has a central role in the control of gene expression, influencing
transcriptional control of many genes, including tumor suppressor genes. PXD101 is a novel …

Acute myeloid leukemia (AML) with t (8; 21)(q22; q22. 1); RUNX1-RUNX1T1, one of the core-
binding factor leukemias, is one of the most common subtypes of AML with recurrent genetic …

To assess the prognostic impact of cytogenetics in elderly patients with acute myeloid
leukemia (AML) receiving intensive induction and consolidation treatment according to a …