During the last 100 years, cell signaling has evolved into a common mechanism for most
physiological processes across systems. Although the majority of cell signaling principles …

Histamine intoxications result when histamine-metabolizing enzymes are compromised or
overwhelmed by dietary histamine in the human body. This can occur either due to …

Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human
physiology. Understanding receptor activation mechanism is critical for discovering novel …

Natural genetic variation in the human genome is a cause of individual differences in
responses to medications and is an underappreciated burden on public health. Although …

Family C G-protein-coupled receptors (GPCRs) operate as obligate dimers with extracellular
domains that recognize small ligands, leading to G-protein activation on the transmembrane …

G-protein-coupled receptors (GPCRs) transduce signals from the extracellular environment
to intracellular proteins. To gain structural insight into the regulation of receptor cytoplasmic …

The formylpeptide receptors (FPRs) mediate pattern recognition of formylated peptides
derived from invading pathogens or mitochondria from dead host cells. They can also sense …

Conspectus Protein function is inextricably linked to protein dynamics. As we move from a
static structural picture to a dynamic ensemble view of protein structure and function, novel …

Metabotropic γ-aminobutyric acid G protein–coupled receptors (GABAB) represent one of
the two main types of inhibitory neurotransmitter receptors in the brain. These receptors act …

G protein‐coupled receptors (GPCRs) play critical roles in the regulation of human
physiology in response to a wide array of different extracellular stimuli and thus represent …