Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Flexibly selecting appropriate actions in response to complex, ever-changing environments
requires both cortical and subcortical regions, which are typically described as participating …

Prefrontal cortex (PFC) is the cognitive center that integrates and regulates global brain
activity. However, the whole-brain organization of PFC axon projections remains poorly …

Psychedelic drugs, including the serotonin 2a (5-HT 2A) receptor partial agonist psilocybin,
are receiving renewed attention for their possible efficacy in treating a variety of …

During sleep and awake rest, the neocortex generates large-scale slow-wave (SW) activity.
Here, we report that the claustrum coordinates neocortical SW generation. We established a …

The claustrum is a brain region that has been investigated for over 200 years, yet its precise
function remains unknown. In the final posthumously released article of Francis Crick, written …

In this 30th anniversary issue review, we focus on the glucocorticoid modulation of limbic‐
prefrontocortical circuitry during stress‐coping. This action of the stress hormone is mediated …

The synthetic opioid fentanyl is a major contributor to the current opioid addiction crisis. We
report that claustral neurons projecting to the frontal cortex limit oral fentanyl self …

The claustrum, a subcortical nucleus forming extensive connections with the neocortex, has
been implicated in sensory selection. Sensory-evoked claustrum activity is thought to …

Humans are immensely curious and motivated to reduce uncertainty, but little is known
about the neural mechanisms that generate curiosity. Curiosity is inversely associated with …