[HTML][HTML] Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain

M Miranda, JF Morici, MB Zanoni… - Frontiers in cellular …, 2019 - frontiersin.org
Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes
related to learning and memory. The expression of BDNF is highly regulated, and can lead …

[HTML][HTML] Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?

GA Porter, JC O'Connor - World journal of psychiatry, 2022 - ncbi.nlm.nih.gov
Major depressive disorder is a debilitating disorder affecting millions of people each year.
Brain-derived neurotrophic factor (BDNF) and inflammation are two prominent biologic risk …

Peripheral levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: a meta-analysis of …

M Solmi, MS Sharma, EF Osimo, M Fornaro… - Brain, Behavior, and …, 2021 - Elsevier
Importance It is unclear whether differences exist in the magnitude and variability of pro-
inflammatory mediators in the different phases of bipolar disorder (BD) and among subjects …

The application of unsupervised clustering methods to Alzheimer's disease

H Alashwal, M El Halaby, JJ Crouse… - Frontiers in …, 2019 - frontiersin.org
Clustering is a powerful machine learning tool for detecting structures in datasets. In the
medical field, clustering has been proven to be a powerful tool for discovering patterns and …

Major depressive disorder and bipolar disorder predispose youth to accelerated atherosclerosis and early cardiovascular disease: a scientific statement from the …

BI Goldstein, MR Carnethon, KA Matthews… - Circulation, 2015 - Am Heart Assoc
In the 2011 “Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk
Reduction in Children and Adolescents,” several medical conditions among youth were …

Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies

A Modabbernia, S Taslimi, E Brietzke, M Ashrafi - Biological psychiatry, 2013 - Elsevier
BACKGROUND: We conducted a meta-analysis of studies comparing cytokine
concentrations between patients with bipolar disorder (BD) and healthy control subjects …

Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors

M Berk, F Kapczinski, AC Andreazza, OM Dean… - … & biobehavioral reviews, 2011 - Elsevier
There is now strong evidence of progressive neuropathological processes in bipolar
disorder (BD). On this basis, the current understanding of the neurobiology of BD has shifted …

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

M Maes, M Berk, L Goehler, C Song, G Anderson… - BMC medicine, 2012 - Springer
It is of considerable translational importance whether depression is a form or a consequence
of sickness behavior. Sickness behavior is a behavioral complex induced by infections and …

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro) degenerative processes in that …

M Maes, P Galecki, YS Chang, M Berk - Progress in Neuro …, 2011 - Elsevier
This paper reviews the body of evidence that major depression is accompanied by a
decreased antioxidant status and by induction of oxidative and nitrosative (IO&NS) …

Biomarkers and clinical staging in psychiatry

P McGorry, M Keshavan, S Goldstone… - World …, 2014 - Wiley Online Library
Personalized medicine is rapidly becoming a reality in today's physical medicine. However,
as yet this is largely an aspirational goal in psychiatry, despite significant advances in our …