Growing evidence has demonstrated that clonogenic cancer stem (initiating) cells are
responsible for tumor regrowth and disease relapse. Bmi‐1 plays a critical role in the self …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder characterized by a
chromosome translocation that generates the Bcr-Abl oncogene encoding a constitutive …

Drug combinations have demonstrated great potential in cancer treatments. They alleviate
drug resistance and improve therapeutic efficacy. The fast-growing number of anti-cancer …

Nowadays, more than 90% of patients affected by chronic myeloid leukemia (CML) survive
with a good quality of life, thanks to the clinical efficacy of tyrosine kinase inhibitors (TKIs) …

The onset of global epigenetic changes in chromatin that drive tumor proliferation and
heterogeneity is a hallmark of many forms of cancer. Identifying the epigenetic mechanisms …

Polycomb group genes (PcGs) are epigenetic effectors, essential for stem cell self-renewal
and pluripotency. Two main Polycomb repressive complexes (PRC1, PRC2) mediate gene …

The BMI1 polycomb protein regulates self-renewal, proliferation and survival of cancer-
initiating cells essentially through epigenetic repression of the CDKN2A tumor suppressor …

Epigenetic programming is an important facet of biology, controlling gene expression
patterns and the choice between developmental pathways. The Polycomb group proteins …

Endometrial cancer (EC) is the third leading gynecological malignancy, and its treatment
remains challenging. B cell-specific Moloney murine leukemia virus integration site-1 (BMI1) …

Background BMI1 is a polycomb group (PcG) protein and is overexpressed in leukemia. It
plays a key role in the self-renewal of stem cells. Leukemic cells lacking BMI1 underwent …