Recent developments and applications of capillary and microchip electrophoresis in proteomics and peptidomics (mid‐2018–2022)

S Štěpánová, V Kašička - Journal of Separation Science, 2023 - Wiley Online Library
This review gives a wide overview of recent advances and applications of capillary
electrophoresis and microchip capillary electrophoresis methods in the fields of proteomics …

Clinical applications of plasma proteomics and peptidomics: Towards precision medicine

B He, Z Huang, C Huang… - PROTEOMICS–Clinical …, 2022 - Wiley Online Library
In the context of precision medicine, disease treatment requires individualized strategies
based on the underlying molecular characteristics to overcome therapeutic challenges …

Reproducibility evaluation of urinary peptide detection using CE-MS

E Mavrogeorgis, H Mischak, A Latosinska, J Siwy… - Molecules, 2021 - mdpi.com
In recent years, capillary electrophoresis coupled to mass spectrometry (CE-MS) has been
increasingly applied in clinical research especially in the context of chronic and age …

Urinary peptidomic profiles to address age-related disabilities: a prospective population study

DS Martens, L Thijs, A Latosinska… - The Lancet Healthy …, 2021 - thelancet.com
Summary Background The Global Burden of Diseases, Injuries, and Risk Factors Study
2019 called for innovation in addressing age-related disabilities. Our study aimed to identify …

Predictive performance and clinical application of COV50, a urinary proteomic biomarker in early COVID-19 infection: a prospective multicentre cohort study

JA Staessen, R Wendt, YL Yu, S Kalbitz… - The Lancet Digital …, 2022 - thelancet.com
Summary Background The SARS-CoV-2 pandemic is a worldwide challenge. The CRIT-
CoV-U pilot study generated a urinary proteomic biomarker consisting of 50 peptides …

Collagen-derived peptides in CKD: a link to fibrosis

E Mavrogeorgis, H Mischak, A Latosinska, A Vlahou… - Toxins, 2021 - mdpi.com
Collagen is a major component of the extracellular matrix (ECM) and has an imminent role
in fibrosis, in, among others, chronic kidney disease (CKD). Collagen alpha-1 (I)(col1a1) is …

A universal predictive and mechanistic urinary peptide signature in acute kidney injury

A Piedrafita, J Siwy, J Klein, A Akkari, A Amaya-Garrido… - Critical Care, 2022 - Springer
Background The delayed diagnosis of acute kidney injury (AKI) episodes and the lack of
specificity of current single AKI biomarkers hamper its management. Urinary peptidome …

A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options

Y Liu, L Song, N Zheng, J Shi, H Wu, X Yang… - Science China Life …, 2022 - Springer
Signaling pathway alterations in COVID-19 of living humans as well as therapeutic targets of
the host proteins are not clear. We analyzed 317 urine proteomes, including 86 COVID-19 …

Prognosis and personalized in silico prediction of treatment efficacy in cardiovascular and chronic kidney disease: a proof-of-concept study

MA Jaimes Campos, I Andújar, F Keller, G Mayer… - Pharmaceuticals, 2023 - mdpi.com
(1) Background: Kidney and cardiovascular diseases are responsible for a large fraction of
population morbidity and mortality. Early, targeted, personalized intervention represents the …

Proteomic characterization of acute kidney injury in patients hospitalized with SARS-CoV2 infection

I Paranjpe, P Jayaraman, CY Su, S Zhou… - Communications …, 2023 - nature.com
Background Acute kidney injury (AKI) is a known complication of COVID-19 and is
associated with an increased risk of in-hospital mortality. Unbiased proteomics using …