The ongoing ability of bacteria to resist current antibiotic treatments highlights the need for
alternative strategies for inhibiting their pathogenicity. For many pathogens, including …

There has been intense interest during recent years in identifying the biological functions of
carbohydrates. This diverse class of biomolecule is now well recognized as playing …

Multivalency is a key principle in reinforcing reversible molecular interactions through the
formation of multiple bonds. The influenza A virus deploys this strategy to bind strongly to …

WbbB, a lipopolysaccharide O-antigen synthesis enzyme from Raoultella terrigena, contains
an N-terminal glycosyltransferase domain with a highly modified architecture that adds a …

Free-radical hydrothiolation of the endocyclic double bond of enoses is reported. Reaction
between 2-acetoxy-d-glucal and a range of thiols including amino acid, peptide, glycosyl …

N-Sulfonyl imidazoles activate 2-deoxy-sugar hemiacetals for glycosylation presumably by
converting them into glycosyl sulfonates in situ. By matching the leaving group ability of the …

Tetra-and octavalent sialoside clusters were prepared in good yields exploiting for the first
time the multiple copper-catalyzed cycloaddition of a propargyl thiosialoside with calix [4] …

The influenza A virus infects target cells through multivalent interactions of its major spike
proteins, hemagglutinin (HA) and neuraminidase (NA), with the cellular receptor sialic acid …

Glycans decorate over 95% of the mammalian cell surface in the form of glycolipids and
glycoproteins. Several toxins and pathogens bind to these glycans to enter the cells …

Glycosidase resistant thioglycoside precursors of the melanoma-associated ganglioside
GM2 have been synthesized starting from lactose. Syntheses of several analogues of …