Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression

GA Stamatiades, UB Kaiser - Molecular and cellular endocrinology, 2018 - Elsevier
The precise orchestration of hormonal regulation at all levels of the hypothalamic-pituitary-
gonadal axis is essential for normal reproductive function and fertility. The pulsatile secretion …

Molecular regulation of follicle-stimulating hormone synthesis, secretion and action

N Das, TR Kumar - Journal of molecular endocrinology, 2018 - jme.bioscientifica.com
Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH
is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The …

Molecular physiology of pituitary development: signaling and transcriptional networks

X Zhu, AS Gleiberman… - Physiological …, 2007 - journals.physiology.org
The pituitary gland is a central endocrine organ regulating basic physiological functions,
including growth, the stress response, reproduction, metabolic homeostasis, and lactation …

GnRH signaling, the gonadotrope and endocrine control of fertility

SP Bliss, AM Navratil, J Xie, MS Roberson - Frontiers in …, 2010 - Elsevier
Mammalian reproductive cycles are controlled by an intricate interplay between the
hypothalamus, pituitary and gonads. Central to the function of this axis is the ability of the …

Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor

Z Naor - Frontiers in neuroendocrinology, 2009 - Elsevier
Gonadotropin-releasing hormone (GnRH) is the first key hormone of reproduction. GnRH
analogs are extensively used in in vitro fertilization, and treatment of sex hormone …

GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression

IR Thompson, UB Kaiser - Molecular and cellular endocrinology, 2014 - Elsevier
The pituitary gonadotropin hormones, FSH and LH, are essential for fertility. Containing an
identical α-subunit (CGA), they are comprised of unique β-subunits, FSHβ and LHβ …

Molecular regulation of hypothalamus–pituitary–gonads axis in males

JM Jin, WX Yang - Gene, 2014 - Elsevier
The hypothalamic–pituitary–gonadal axis (HPG) plays vital roles in reproduction and steroid
hormone production in both sexes. The focus of this review is upon gene structures, receptor …

Hormones in synergy: regulation of the pituitary gonadotropin genes

VG Thackray, PL Mellon, D Coss - Molecular and cellular endocrinology, 2010 - Elsevier
The precise interplay of hormonal influences that governs gonadotropin hormone production
by the pituitary includes endocrine, paracrine and autocrine actions of hypothalamic …

[HTML][HTML] Mechanisms of FSH synthesis: what we know, what we don't, and why you should care

DJ Bernard, J Fortin, Y Wang, P Lamba - Fertility and sterility, 2010 - Elsevier
The pituitary gonadotropin hormones, FSH and LH, are key regulators of reproductive
physiology. Though the two hormones are produced by the same cell type, often in response …

Regulation of gonadotropins by inhibin and activin

SJ Gregory, UB Kaiser - Seminars in reproductive medicine, 2004 - thieme-connect.com
Inhibin, activin, and follistatin were first identified as gonadal hormones that could exert
selective effects on follicle-stimulating hormone (FSH) secretion without affecting luteinizing …