Extramedullary hematopoiesis (EMH) is the formation and development of blood cells
outside the medullary spaces of the bone marrow. Although widely considered an …

"'The Genetic Connection'is a complete guide to breed-related medical problems in
purebred dogs and cats. Comprehensive but conveniently divided by body systems, this …

Gene transfer is a novel area of therapeutics in which the active agent is a nucleic acid
rather than a protein or small molecule. As early as 1997, investigators reported long‐term …

SCID patients have been successfully treated by administration of ex vivo gene-corrected
stem cells. However, despite its proven efficacy, such treatment carries specific risks and …

Manipulation of gene expression is an invaluable tool to study gene function in vitro and in
vivo. The application of small inhibitory RNAs to knock down gene expression provides a …

Genetic mutations involving the cellular components of the hematopoietic system—red
blood cells, white blood cells, and platelets—manifest clinically as anemia, infection, and …

641 ticularly dirofilariasis); hypersensitivity reactions; inflammation; neoplasia (basophilic
leukemia, mast cell tumor/mastocytosis, lymphomatoid granulomatosis, essential …

Primary immunodeficiency diseases represent good targets for hematopoietic stem cell-
targeted gene therapy. Severe combined immunodeficiencies (SCID) have been the first …

Cyclic neutropenia occurs in humans and gray collie dogs, is characterized by recurrent
neutropenia, and is treated by daily injections of recombinant granulocyte colony-stimulating …

Cyclic neutropenia occurs in humans and gray collie dogs, is characterized by recurrent
neutropenia, and is treated by repeated injections of recombinant granulocyte colony …