Branched chain amino acids (BCAAs) are building blocks for all life-forms. We review here
the fundamentals of BCAA metabolism in mammalian physiology. Decades of studies have …

Ketone body metabolism is a central node in physiological homeostasis. In this review, we
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …

Acute physical activity leads to several changes in metabolic, cardiovascular, and immune
pathways. Although studies have examined selected changes in these pathways, the system …

Elevations in branched-chain amino acids (BCAAs) associate with numerous systemic
diseases, including cancer, diabetes, and heart failure. However, an integrated …

Several metabolic alterations accumulate over time along with a reduction in biological
fitness, suggesting the existence of a" metabolic clock" that controls aging. Multiple inborn …

Acetyl-coenzyme A (acetyl-CoA) is a central metabolic intermediate. The abundance of
acetyl-CoA in distinct subcellular compartments reflects the general energetic state of the …

Metabolomics generates a profile of small molecules that are derived from cellular
metabolism and can directly reflect the outcome of complex networks of biochemical …

Circulating levels of undercarboxylated and bioactive osteocalcin double during aerobic
exercise at the time levels of insulin decrease. In contrast, circulating levels of osteocalcin …

Post-translational modification of lysine residues via reversible acylation occurs on proteins
from diverse pathways, functions, and organisms. While nuclear protein acylation reflects the …

While the timing of food intake is important, it is unclear whether the effects of exercise on
energy metabolism are restricted to unique time windows. As circadian regulation is key to …