[HTML][HTML] The sirtuin family in health and disease

QJ Wu, TN Zhang, HH Chen, XF Yu, JL Lv… - … and Targeted Therapy, 2022 - nature.com
Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Sirtuin activators and inhibitors

JM Villalba, FJ Alcaín - Biofactors, 2012 - Wiley Online Library
Abstract Sirtuins 1‐7 (SIRT1‐7) belong to the third class of deacetylase enzymes, which are
dependent on NAD+ for activity. Sirtuins activity is linked to gene repression, metabolic …

CD38 and CD157: a long journey from activation markers to multifunctional molecules

V Quarona, G Zaccarello, A Chillemi… - Cytometry Part B …, 2013 - Wiley Online Library
CD38 (also known as T10) was identified in the late 1970s in the course of pioneering work
carried out at the Dana‐Farber Cancer Center (Boston, MA) that focused on the identification …

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

RE Castro, DMS Ferreira, MB Afonso, PM Borralho… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of
stages from simple steatosis to non-alcoholic steatohepatitis (NASH). However, disease …

[HTML][HTML] miR-34: from bench to bedside

M Agostini, RA Knight - Oncotarget, 2014 - ncbi.nlm.nih.gov
The mir-34 family was originally cloned and characterized in 2007 as a p53 target gene.
Almost immediately it became clear that its major role is as a master regulator of tumor …

Roles of pyridine and pyrimidine derivatives as privileged scaffolds in anticancer agents

S Prachayasittikul, R Pingaew… - Mini Reviews in …, 2017 - ingentaconnect.com
Background: Cancer has been considered to be a global health concern due to the impact of
disease on the quality of life. The continual increase of cancer cases as well as the …

The role of sirtuins in aging and age-related diseases

M Wątroba, D Szukiewicz - Advances in medical sciences, 2016 - Elsevier
Sirtuins, initially described as histone deacetylases and gene silencers in yeast, are now
known to have much more functions and to be much more abundant in living organisms …

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia

V Audrito, S Serra, D Brusa, F Mazzola… - Blood, The Journal …, 2015 - ashpublications.org
Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in
nicotinamide adenine dinucleotide biosynthesis. In the extracellular compartment, it exhibits …

Sirtuin inhibitors as anticancer agents

J Hu, H Jing, H Lin - Future medicinal chemistry, 2014 - Taylor & Francis
Sirtuins are a class of enzymes with nicotinamide adenine dinucleotide (NAD)-dependent
protein lysine deacylase function. By deacylating various substrate proteins, including …

Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress …

MT Do, HG Kim, JH Choi, HG Jeong - Free Radical Biology and Medicine, 2014 - Elsevier
Abstract Sirtuin 1 (Sirt1) plays an important role in cellular redox balance and resistance to
oxidative stress. Sirt1 exhibits oncogenic properties in wild-type p53 cancer cells, whereas it …