Spine dynamics in the brain, mental disorders and artificial neural networks

H Kasai, NE Ziv, H Okazaki, S Yagishita… - Nature Reviews …, 2021 - nature.com
In the brain, most synapses are formed on minute protrusions known as dendritic spines.
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …

Adaptive control of synaptic plasticity integrates micro-and macroscopic network function

DN Scott, MJ Frank - Neuropsychopharmacology, 2023 - nature.com
Synaptic plasticity configures interactions between neurons and is therefore likely to be a
primary driver of behavioral learning and development. How this microscopic-macroscopic …

Drifting assemblies for persistent memory: Neuron transitions and unsupervised compensation

YF Kalle Kossio, S Goedeke, C Klos… - Proceedings of the …, 2021 - National Acad Sciences
Change is ubiquitous in living beings. In particular, the connectome and neural
representations can change. Nevertheless, behaviors and memories often persist over long …

Learning-induced biases in the ongoing dynamics of sensory representations predict stimulus generalization

DF Aschauer, JB Eppler, L Ewig, AR Chambers… - Cell reports, 2022 - cell.com
Sensory stimuli have long been thought to be represented in the brain as activity patterns of
specific neuronal assemblies. However, we still know relatively little about the long-term …

Homeostatic mechanisms regulate distinct aspects of cortical circuit dynamics

YK Wu, KB Hengen, GG Turrigiano… - Proceedings of the …, 2020 - National Acad Sciences
Homeostasis is indispensable to counteract the destabilizing effects of Hebbian plasticity.
Although it is commonly assumed that homeostasis modulates synaptic strength, membrane …

Edge of chaos and avalanches in neural networks with heavy-tailed synaptic weight distribution

Ł Kuśmierz, S Ogawa, T Toyoizumi - Physical Review Letters, 2020 - APS
We propose an analytically tractable neural connectivity model with power-law distributed
synaptic strengths. When threshold neurons with biologically plausible number of incoming …

Activity dependent and independent determinants of synaptic size diversity

L Hazan, NE Ziv - Journal of Neuroscience, 2020 - Soc Neuroscience
The extraordinary diversity of excitatory synapse sizes is commonly attributed to activity-
dependent processes that drive synaptic growth and diminution. Recent studies also point to …

A stable sensory map emerges from a dynamic equilibrium of neurons with unstable tuning properties

AR Chambers, DF Aschauer, JB Eppler… - Cerebral …, 2023 - academic.oup.com
Recent long-term measurements of neuronal activity have revealed that, despite stability in
large-scale topographic maps, the tuning properties of individual cortical neurons can …

Linking spontaneous and stimulated spine dynamics

MF Eggl, TE Chater, J Petkovic, Y Goda… - Communications …, 2023 - nature.com
Our brains continuously acquire and store memories through synaptic plasticity. However,
spontaneous synaptic changes can also occur and pose a challenge for maintaining stable …

Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition

H Kasai - Proceedings of the Japan Academy, Series B, 2023 - jstage.jst.go.jp
Recent research extends our understanding of brain processes beyond just action potentials
and chemical transmissions within neural circuits, emphasizing the mechanical forces …