Spine dynamics in the brain, mental disorders and artificial neural networks
In the brain, most synapses are formed on minute protrusions known as dendritic spines.
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …
Adaptive control of synaptic plasticity integrates micro-and macroscopic network function
Synaptic plasticity configures interactions between neurons and is therefore likely to be a
primary driver of behavioral learning and development. How this microscopic-macroscopic …
primary driver of behavioral learning and development. How this microscopic-macroscopic …
Drifting assemblies for persistent memory: Neuron transitions and unsupervised compensation
Change is ubiquitous in living beings. In particular, the connectome and neural
representations can change. Nevertheless, behaviors and memories often persist over long …
representations can change. Nevertheless, behaviors and memories often persist over long …
Learning-induced biases in the ongoing dynamics of sensory representations predict stimulus generalization
DF Aschauer, JB Eppler, L Ewig, AR Chambers… - Cell reports, 2022 - cell.com
Sensory stimuli have long been thought to be represented in the brain as activity patterns of
specific neuronal assemblies. However, we still know relatively little about the long-term …
specific neuronal assemblies. However, we still know relatively little about the long-term …
Homeostatic mechanisms regulate distinct aspects of cortical circuit dynamics
Homeostasis is indispensable to counteract the destabilizing effects of Hebbian plasticity.
Although it is commonly assumed that homeostasis modulates synaptic strength, membrane …
Although it is commonly assumed that homeostasis modulates synaptic strength, membrane …
Edge of chaos and avalanches in neural networks with heavy-tailed synaptic weight distribution
We propose an analytically tractable neural connectivity model with power-law distributed
synaptic strengths. When threshold neurons with biologically plausible number of incoming …
synaptic strengths. When threshold neurons with biologically plausible number of incoming …
Activity dependent and independent determinants of synaptic size diversity
L Hazan, NE Ziv - Journal of Neuroscience, 2020 - Soc Neuroscience
The extraordinary diversity of excitatory synapse sizes is commonly attributed to activity-
dependent processes that drive synaptic growth and diminution. Recent studies also point to …
dependent processes that drive synaptic growth and diminution. Recent studies also point to …
A stable sensory map emerges from a dynamic equilibrium of neurons with unstable tuning properties
AR Chambers, DF Aschauer, JB Eppler… - Cerebral …, 2023 - academic.oup.com
Recent long-term measurements of neuronal activity have revealed that, despite stability in
large-scale topographic maps, the tuning properties of individual cortical neurons can …
large-scale topographic maps, the tuning properties of individual cortical neurons can …
Linking spontaneous and stimulated spine dynamics
MF Eggl, TE Chater, J Petkovic, Y Goda… - Communications …, 2023 - nature.com
Our brains continuously acquire and store memories through synaptic plasticity. However,
spontaneous synaptic changes can also occur and pose a challenge for maintaining stable …
spontaneous synaptic changes can also occur and pose a challenge for maintaining stable …
Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition
H Kasai - Proceedings of the Japan Academy, Series B, 2023 - jstage.jst.go.jp
Recent research extends our understanding of brain processes beyond just action potentials
and chemical transmissions within neural circuits, emphasizing the mechanical forces …
and chemical transmissions within neural circuits, emphasizing the mechanical forces …