[HTML][HTML] Host genetics and infectious disease: new tools, insights and translational opportunities
Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
Host–parasite co-evolution and its genomic signature
Studies in diverse biological systems have indicated that host–parasite co-evolution is
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …
[HTML][HTML] International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact
Background Pneumococcal conjugate vaccines have reduced the incidence of invasive
pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a …
pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a …
[HTML][HTML] Malaria protection due to sickle haemoglobin depends on parasite genotype
G Band, EM Leffler, M Jallow, F Sisay-Joof, CM Ndila… - Nature, 2022 - nature.com
Host genetic factors can confer resistance against malaria, raising the question of whether
this has led to evolutionary adaptation of parasite populations. Here we searched for …
this has led to evolutionary adaptation of parasite populations. Here we searched for …
[HTML][HTML] Next-generation microbiology: from comparative genomics to gene function
Microbiology is at a turning point in its 120-year history. Widespread next-generation
sequencing has revealed genetic complexity among bacteria that could hardly have been …
sequencing has revealed genetic complexity among bacteria that could hardly have been …
[HTML][HTML] Acute bacterial meningitis
Acute bacterial meningitis : Current Opinion in Neurology Acute bacterial meningitis :
Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe Get new …
Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe Get new …
Improved prediction of bacterial genotype-phenotype associations using interpretable pangenome-spanning regressions
Discovery of genetic variants underlying bacterial phenotypes and the prediction of
phenotypes such as antibiotic resistance are fundamental tasks in bacterial genomics …
phenotypes such as antibiotic resistance are fundamental tasks in bacterial genomics …
Community-acquired bacterial meningitis
Progress has been made in the prevention and treatment of community-acquired bacterial
meningitis during the past three decades but the burden of the disease remains high …
meningitis during the past three decades but the burden of the disease remains high …
[HTML][HTML] Genome wide association study of Escherichia coli bloodstream infection isolates identifies genetic determinants for the portal of entry but not fatal outcome
E Denamur, B Condamine, M Esposito-Farèse… - PLoS …, 2022 - journals.plos.org
Escherichia coli is an important cause of bloodstream infections (BSI), which is of concern
given its high mortality and increasing worldwide prevalence. Finding bacterial genetic …
given its high mortality and increasing worldwide prevalence. Finding bacterial genetic …
[HTML][HTML] Current affairs of microbial genome-wide association studies: approaches, bottlenecks and analytical pitfalls
Microbial genome-wide association studies (mGWAS) are a new and exciting research field
that is adapting human GWAS methods to understand how variations in microbial genomes …
that is adapting human GWAS methods to understand how variations in microbial genomes …