Despite decades of bile acid research, diverse biological roles for bile acids have been
discovered recently due to developments in understanding the human microbiota. As …

Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …

Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal
diseases that threaten the health of an increasing number of individuals as their lifestyles …

The trillions of microorganisms in the human intestine are important regulators of health, and
disruptions in the gut microbial communities can cause disease. The gut, liver and immune …

Bile acids play key roles in gut metabolism, cell signaling, and microbiome composition.
While the liver is responsible for the production of primary bile acids, microbes in the gut …

Fecal microbial community changes are associated with numerous disease states, including
cardiovascular disease (CVD). However, such data are merely associative. A causal …

The diverse and dynamic microbial community of the human gastrointestinal tract plays a
vital role in health, with gut microbiota supporting the development and function of the gut …

Changes in the composition of gut-associated microbial communities are associated with
many human illnesses, but the factors driving dysbiosis remain incompletely understood …

A key role of the gut microbiota in the establishment and maintenance of health, as well as in
the pathogenesis of disease, has been identified over the past two decades. One of the …

A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …