Cortical domains are often specified by the local accumulation of active GTPases. Such
domains can arise through spontaneous symmetry-breaking, suggesting that GTPase …

Abstract The Rho GTPase Cdc42 is a central regulator of cell polarity in diverse cell types.
The activity of Cdc42 is dynamically controlled in time and space to enable distinct …

A multiprotein complex polarisome nucleates actin cables for polarized cell growth in
budding yeast and filamentous fungi. However, the dynamic regulations of polarisome …

Yeast cells track gradients of pheromones to locate mating partners. Intuition suggests that
uniform distribution of pheromone receptors over the cell surface would yield optimal …

In Schizosaccharomyces pombe, cytokinesis requires the assembly and constriction of an
actomyosin-based contractile ring (CR). Nucleation of F-actin for the CR requires a single …

Accurate detection of extracellular chemical gradients is essential for many cellular
behaviors. Gradient sensing is challenging for small cells, which can experience little …

Cell organization requires motor-dependent transport of specific cargos along cytoskeletal
elements. How the delivery cycle is coordinated with other events is poorly understood. Here …

Apical secretion from epithelial tubes of the Drosophila embryo is mediated by apical F-actin
cables generated by the formin-family protein Diaphanous (Dia). Apical localization and …

Dynamic assembly and remodeling of actin is critical for many cellular processes during
development and stress adaptation. In filamentous fungi and budding yeast, actin cables …

Both de novo–assembled actin filaments at the division site and existing filaments recruited
by directional cortical transport contribute to contractile ring formation during cytokinesis …