Sialic acids, existing as terminal sugars of glycoconjugates, play important roles in various
physiological and pathological processes, such as cell–cell adhesion, immune defense …

Hypersialylation of tumor cell surface proteins along with a marked upregulation of
sialyltransferase (ST) activity is a well‐established hallmark of cancer. Due to the critical role …

We describe a standardized approach for searching potent and selective inhibitors of
glycosyltransferases by high throughput quantitative MALDI-TOFMS-based screening of …

Sialylconjugates on cell surfaces are involved in many biological events such as cellular
recognition, signal transduction, and immune response. It has been reported that aberrant …

Oligosaccharides in glycoconjugates such as glycoproteins and glycolipids play important
roles in a variety of biological functions. Since glycosyltransferases are responsible for the …

Abstract Human β-galactoside α-2, 6-sialyltransferase I (ST6Gal I) catalyses the synthesis of
sialylated glycoconjugates. Overexpression of ST6Gal I is observed in many cancers, where …

Abnormal glycosylation is a common feature in disease that typically results from
misregulation in expression and/or activity of glycosyltransferases (GTs) and glycosidases …

Human β‐galactoside α‐2, 6‐sialyltransferase I (hST6Gal I) catalyses the synthesis of
sialylated glycoconjugates involved in cell–cell interactions. Overexpression of hST6Gal I is …

Glycosyltransferases and glycosidases work together to construct the oligosaccharide
moieties of biologically active glycoconjugates. Although many excellent glycosidase …

Sialyltransferases (STs) are involved in the biosynthesis of glycoconjugates with important
biological activities. Most STs utilize cytidine-5 '-monophospho-N-acetylneuraminic acid …