Cotranslational folding of proteins on the ribosome
M Liutkute, E Samatova, MV Rodnina - Biomolecules, 2020 - mdpi.com
Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide
exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the …
exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the …
On folding of entangled proteins: knots, lassos, links and θ-curves
JI Sulkowska - Current opinion in structural biology, 2020 - Elsevier
Around 6% of protein structures deposited in the PDB are entangled, forming knots,
slipknots, lassos, links, and θ-curves. In each of these cases, the protein backbone weaves …
slipknots, lassos, links, and θ-curves. In each of these cases, the protein backbone weaves …
How synonymous mutations alter enzyme structure and function over long timescales
The specific activity of enzymes can be altered over long timescales in cells by synonymous
mutations that alter a messenger RNA molecule's sequence but not the encoded protein's …
mutations that alter a messenger RNA molecule's sequence but not the encoded protein's …
AlphaFold predicts novel human proteins with knots
The fact that proteins can have their chain formed in a knot is known for almost 30 years.
However, as they are not common, only a fraction of such proteins is available in the Protein …
However, as they are not common, only a fraction of such proteins is available in the Protein …
Topoly: Python package to analyze topology of polymers
P Dabrowski-Tumanski, P Rubach… - Briefings in …, 2021 - academic.oup.com
The increasing role of topology in (bio) physical properties of matter creates a need for an
efficient method of detecting the topology of a (bio) polymer. However, the existing tools …
efficient method of detecting the topology of a (bio) polymer. However, the existing tools …
Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and less functional
Some misfolded protein conformations can bypass proteostasis machinery and remain
soluble in vivo. This is an unexpected observation, as cellular quality control mechanisms …
soluble in vivo. This is an unexpected observation, as cellular quality control mechanisms …
Mechanical regulation of talin through binding and history-dependent unfolding
Talin is a force-sensing multidomain protein and a major player in cellular
mechanotransduction. Here, we use single-molecule magnetic tweezers to investigate the …
mechanotransduction. Here, we use single-molecule magnetic tweezers to investigate the …
Topological dynamics of an intrinsically disordered N‐terminal domain of the human androgen receptor
Human androgen receptor contains a large N‐terminal domain (AR‐NTD) that is highly
dynamic and this poses a major challenge for experimental and computational analysis to …
dynamic and this poses a major challenge for experimental and computational analysis to …
Are there double knots in proteins? Prediction and in vitro verification based on TrmD-Tm1570 fusion from C. nitroreducens
AP Perlinska, ML Nguyen, SP Pilla… - Frontiers in Molecular …, 2024 - frontiersin.org
We have been aware of the existence of knotted proteins for over 30 years—but it is hard to
predict what is the most complicated knot that can be formed in proteins. Here, we show new …
predict what is the most complicated knot that can be formed in proteins. Here, we show new …
Topological principles of protein folding
B Scalvini, V Sheikhhassani… - Physical Chemistry …, 2021 - pubs.rsc.org
What is the topology of a protein and what governs protein folding to a specific topology?
This is a fundamental question in biology. The protein folding reaction is a critically important …
This is a fundamental question in biology. The protein folding reaction is a critically important …