Most mitochondrial mRNAs in kinetoplastids require editing, that is, the posttranscriptional
insertion and deletion of uridine nucleotides that are specified by guide RNAs and catalyzed …

RNA editing, which adds sequence information to RNAs post‐transcriptionally, is a
widespread phenomenon throughout eukaryotes. The most complex form of this process is …

Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on
health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast …

Kinetoplastids are flagellated protozoans, whose members include the pathogens
Trypanosoma brucei, T. cruzi and Leishmania species, that are considered among the …

African trypanosomes, early diverged eukaryotes and the agents of sleeping sickness, have
several basic cellular processes that are remarkably divergent from those in their …

T4 RNA ligase 2 (Rnl2) exemplifies an RNA ligase family that includes the RNA editing
ligases (RELs) of Trypanosoma and Leishmania. The Rnl2/REL enzymes are defined by …

The mitochondrial F0F1 ATP synthase is an essential multi-subunit protein complex in the
vast majority of eukaryotes but little is known about its composition and role in Trypanosoma …

Trypanosomatid RNA editing is a unique process and essential for these organisms. It
therefore represents a drug target for a group of protozoa that includes the causative agents …

Mitochondrial mRNA editing in trypanosomes is a posttranscriptional processing pathway
thereby uridine residues (Us) are inserted into, or deleted from, messenger RNA precursors …

RNA editing is a process that alters DNA-encoded sequences and is distinct from splicing,
5′ capping, and 3′ additions. In 30 years since editing was discovered in mitochondria of …