Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane,
where its assembly into cage-like lattices underlies the clathrin-coated pits of classical …

The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

Phospholipids are emerging as novel second messengers in plant cells. They are rapidly
formed in response to a variety of stimuli via the activation of lipid kinases or …

PX domains are found in a variety of proteins that associate with cell membranes, but their
molecular function has remained obscure. We show here that the PX domains in p47phox …

Abstract Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs covalently bound topoisomerase
I–DNA complexes 1, 2, 3 and is essential for preventing the formation of double-strand …

The size of endocytic clathrin-coated vesicles (CCVs) is remarkably uniform, suggesting that
it is optimized to achieve the appropriate levels of cargo and lipid internalization. The three …

▪ Abstract There has recently been considerable progress in understanding the regulation of
clathrin-coated vesicle (CCV) formation and function. These advances are due to the …

Inwardly rectifying K+(Kir) channels are important regulators of resting membrane potential
and cell excitability. The activity of Kir channels is critically dependent on the integrity of …

BAR and ENTH domains are families of α-helical lipid bilayer binding modules found in
proteins that function in endocytosis, actin regulation and signaling. Several members of …

Phosphoinositides serve as intrinsic membrane signals that regulate intracellular membrane
trafficking. Recently, phosphoinositides have been found to direct the localization and …