The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic
function by mediating the homing of progenitor cells in the bone marrow and regulating their …

The blood flow through vessels produces a tangential, or shear, stress sensed by their
innermost layer (ie, endothelium) and representing a major hemodynamic force. In humans …

Objective—The Cxcl12/Cxcr4 chemokine ligand/receptor axis mediates the mobilization of
smooth muscle cell progenitors, driving injury-induced neointimal hyperplasia. This study …

Much has been learned about the mechanisms underlying tumor angiogenesis, and
therapies that target vascular endothelial growth factor (VEGF) to limit tumor angiogenesis …

Abstract Background Endothelial progenitor cells (EPCs) play important roles in the
regeneration of the vascular endothelial cells (ECs). Platelet-derived growth factor receptor …

Distinct histone modifications regulate gene expression in certain diseases, but little is
known about histone epigenetics in middle ear cholesteatoma. It is known that histone …

Abstract Background The Forkhead/Fox transcription factor Foxc2 is a critical regulator of
osteogenesis and angiogenesis of cells. Bone marrow mesenchymal stem cells (BMSCs) …

Metastatic melanoma is an aggressive and deadly disease. The chemokine receptor
CXCR4 is active in melanoma metastasis, although the mechanism for the promotion and …

Ischemic heart disease is the most common cause of cardiovascular morbidity and mortality
in the industrialized world, about 1 million myocardial infarctions occur annually in the USA …

Macrophages are largely involved in the whole process of atherosclerosis from an initiation
lesion to an advanced lesion. Endothelial disruption is the initial step and macrophage …