Novel N-Substituted Amino Acid Hydrazone-Isatin Derivatives: Synthesis, Antioxidant Activity, and Anticancer Activity in 2D and 3D Models In Vitro
I Tumosienė, I Jonuškienė, K Kantminienė… - International Journal of …, 2021 - mdpi.com
A series of novel mono and bishydrazones each bearing a 2-oxindole moiety along with
substituted phenylaminopropanamide, pyrrolidin-2-one, benzimidazole, diphenylmethane …
substituted phenylaminopropanamide, pyrrolidin-2-one, benzimidazole, diphenylmethane …
Synthesis of novel thiazole derivatives bearing Β-amino acid and aromatic Moieties as promising scaffolds for the development of new antibacterial and antifungal …
D Malūkaitė, B Grybaitė, R Vaickelionienė… - Molecules, 2021 - mdpi.com
Rapidly growing antimicrobial resistance among clinically important bacterial and fungal
pathogens accounts for high morbidity and mortality worldwide. Therefore, it is critical to look …
pathogens accounts for high morbidity and mortality worldwide. Therefore, it is critical to look …
Synthesis of novel sulphamethoxazole derivatives and exploration of their anticancer and antimicrobial properties
R Vaickelionienė, V Petrikaitė, I Vaškevičienė… - Plos one, 2023 - journals.plos.org
A series of new derivatives based on sulfamethoxazole were designed and synthesized in
this study. The structures of the new compounds were confirmed based on a comprehensive …
this study. The structures of the new compounds were confirmed based on a comprehensive …
Antioxidant and anticancer activity of novel derivatives of 3-[(4-methoxyphenyl) amino] propanehydrazide
I Tumosienė, K Kantminienė, A Klevinskas, V Petrikaitė… - Molecules, 2020 - mdpi.com
Series of novel 3-[(4-methoxyphenyl) amino] propanehydrazide derivatives bearing
semicarbazide, thiosemicarbazide, thiadiazole, triazolone, triazolethione, thiophenyltriazole …
semicarbazide, thiosemicarbazide, thiadiazole, triazolone, triazolethione, thiophenyltriazole …
Synthesis of novel 1, 2-and 2-substituted benzimidazoles with high antibacterial and antioxidant activity
I Tumosienė, A Peleckis, I Jonuškienė… - Monatshefte für Chemie …, 2018 - Springer
Benzimidazole derivatives are potential candidates for drug development. They are
efficiently synthesized and possess various biological properties including antibacterial …
efficiently synthesized and possess various biological properties including antibacterial …
Synthesis and structure–affinity relationship of chlorinated pyrrolidinone-bearing benzenesulfonamides as human carbonic anhydrase inhibitors
B Balandis, G Ivanauskaitė, J Smirnovienė… - Bioorganic …, 2020 - Elsevier
A novel set of pyrrolidinone-based chlorinated benzenesulfonamide derivatives were
synthesized and investigated for their binding affinity and selectivity against recombinant …
synthesized and investigated for their binding affinity and selectivity against recombinant …
Synthesis, Characterization and Antibacterial Assays of Novel N,N1‐Disubstituted 2,2′‐Dithiodianiline Derivatives
K Skrickus, J Šiugždaitė, R Lelešius… - …, 2023 - Wiley Online Library
Abstract A series of novel 1, 2‐bissubstituted disulfanes bearing beta‐amino acid,
dihydropyrimidine‐2, 4‐(1H, 3H)‐dione, hydrazide, hydrazone and azole moieties were …
dihydropyrimidine‐2, 4‐(1H, 3H)‐dione, hydrazide, hydrazone and azole moieties were …
Beta and gamma amino acid-substituted benzenesulfonamides as inhibitors of human carbonic anhydrases
B Balandis, T Šimkūnas, V Paketurytė-Latvė… - Pharmaceuticals, 2022 - mdpi.com
A series of novel benzenesulfonamide derivatives were synthesized bearing para-N β, γ-
amino acid or para-N β-amino acid and thiazole moieties and their binding to the human …
amino acid or para-N β-amino acid and thiazole moieties and their binding to the human …
Synthesis and Development of N-2,5-Dimethylphenylthioureido Acid Derivatives as Scaffolds for New Antimicrobial Candidates Targeting Multidrug-Resistant Gram …
P Kavaliauskas, B Grybaitė, R Vaickelionienė… - Antibiotics, 2023 - mdpi.com
The growing antimicrobial resistance to last-line antimicrobials among Gram-positive
pathogens remains a major healthcare emergency worldwide. Therefore, the search for new …
pathogens remains a major healthcare emergency worldwide. Therefore, the search for new …
Synthesis and antimicrobial activity of novel thiazoles with reactive functional groups
B Grybaitė, R Vaickelionienė, M Stasevych… - …, 2019 - Wiley Online Library
A series of substituted thiazoles bearing different functional groups, such as
carboxyethylamino, carboxyl, chloromethyl,(phenylamino) methyl, ethoxyoxoethyl …
carboxyethylamino, carboxyl, chloromethyl,(phenylamino) methyl, ethoxyoxoethyl …