Purinergic signalling in the musculoskeletal system
It is now widely recognised that extracellular nucleotides, signalling via purinergic receptors,
participate in numerous biological processes in most tissues. It has become evident that …
participate in numerous biological processes in most tissues. It has become evident that …
Systemic nutrient and stress signaling via myokines and myometabolites
M Rai, F Demontis - Annual review of physiology, 2016 - annualreviews.org
Homeostatic systems mount adaptive responses to meet the energy demands of the cell and
to compensate for dysfunction in cellular compartments. Such surveillance systems are also …
to compensate for dysfunction in cellular compartments. Such surveillance systems are also …
ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle
ATP released from cells is known to activate plasma membrane P2X (ionotropic) or P2Y
(metabotropic) receptors. In skeletal muscle cells, depolarizing stimuli induce both a fast …
(metabotropic) receptors. In skeletal muscle cells, depolarizing stimuli induce both a fast …
The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels
During repetitive stimulation of skeletal muscle, extracellular ATP levels raise, activating
purinergic receptors, increasing Ca 2+ influx, and enhancing contractile force, a response …
purinergic receptors, increasing Ca 2+ influx, and enhancing contractile force, a response …
De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy
Denervation of skeletal muscles induces atrophy, preceded by changes in sarcolemma
permeability of causes not yet completely understood. Here, we show that denervation …
permeability of causes not yet completely understood. Here, we show that denervation …
Effect of dietary methionine level on muscle growth mechanisms in juvenile rainbow trout (Oncorhynchus mykiss)
H Alami-Durante, D Bazin, M Cluzeaud… - Aquaculture, 2018 - Elsevier
The aim of the study was to analyse the effects of different dietary methionine (Met)
concentrations on the mechanisms of fish muscle growth (hyperplasia and hypertrophy) by …
concentrations on the mechanisms of fish muscle growth (hyperplasia and hypertrophy) by …
A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90
CNJ Young, A Sinadinos, A Lefebvre, P Chan, S Arkle… - Autophagy, 2015 - Taylor & Francis
P2RX7 is an ATP-gated ion channel, which can also exhibit an open state with a
considerably wider permeation. However, the functional significance of the movement of …
considerably wider permeation. However, the functional significance of the movement of …
Acetic acid stimulates G-protein-coupled receptor GPR43 and induces intracellular calcium influx in L6 myotube cells
H Maruta, H Yamashita - PLoS One, 2020 - journals.plos.org
Short chain fatty acids (SCFAs) produced endogenously in the gut by bacterial fermentation
of dietary fiber have been studied as nutrients that act as signaling molecules to activate G …
of dietary fiber have been studied as nutrients that act as signaling molecules to activate G …
The Impact of H2S on Obesity-Associated Metabolic Disturbances
F Comas, JM Moreno-Navarrete - Antioxidants, 2021 - mdpi.com
Over the last several decades, hydrogen sulfide (H2S) has gained attention as a new
signaling molecule, with extensive physiological and pathophysiological roles in human …
signaling molecule, with extensive physiological and pathophysiological roles in human …
Pannexin 1 and pannexin 3 channels regulate skeletal muscle myoblast proliferation and differentiation
S Langlois, X Xiang, K Young, BJ Cowan… - Journal of Biological …, 2014 - ASBMB
Pannexins constitute a family of three glycoproteins (Panx1,-2, and-3) forming single
membrane channels. Recent work demonstrated that Panx1 is expressed in skeletal muscle …
membrane channels. Recent work demonstrated that Panx1 is expressed in skeletal muscle …