Purinergic signalling in the musculoskeletal system

G Burnstock, TR Arnett, IR Orriss - Purinergic signalling, 2013 - Springer
It is now widely recognised that extracellular nucleotides, signalling via purinergic receptors,
participate in numerous biological processes in most tissues. It has become evident that …

Systemic nutrient and stress signaling via myokines and myometabolites

M Rai, F Demontis - Annual review of physiology, 2016 - annualreviews.org
Homeostatic systems mount adaptive responses to meet the energy demands of the cell and
to compensate for dysfunction in cellular compartments. Such surveillance systems are also …

ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle

S Buvinic, G Almarza, M Bustamante, M Casas… - Journal of Biological …, 2009 - ASBMB
ATP released from cells is known to activate plasma membrane P2X (ionotropic) or P2Y
(metabotropic) receptors. In skeletal muscle cells, depolarizing stimuli induce both a fast …

The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels

MA Riquelme, LA Cea, JL Vega, MP Boric, H Monyer… - …, 2013 - Elsevier
During repetitive stimulation of skeletal muscle, extracellular ATP levels raise, activating
purinergic receptors, increasing Ca 2+ influx, and enhancing contractile force, a response …

De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy

LA Cea, BA Cisterna, C Puebla… - Proceedings of the …, 2013 - National Acad Sciences
Denervation of skeletal muscles induces atrophy, preceded by changes in sarcolemma
permeability of causes not yet completely understood. Here, we show that denervation …

Effect of dietary methionine level on muscle growth mechanisms in juvenile rainbow trout (Oncorhynchus mykiss)

H Alami-Durante, D Bazin, M Cluzeaud… - Aquaculture, 2018 - Elsevier
The aim of the study was to analyse the effects of different dietary methionine (Met)
concentrations on the mechanisms of fish muscle growth (hyperplasia and hypertrophy) by …

A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90

CNJ Young, A Sinadinos, A Lefebvre, P Chan, S Arkle… - Autophagy, 2015 - Taylor & Francis
P2RX7 is an ATP-gated ion channel, which can also exhibit an open state with a
considerably wider permeation. However, the functional significance of the movement of …

Acetic acid stimulates G-protein-coupled receptor GPR43 and induces intracellular calcium influx in L6 myotube cells

H Maruta, H Yamashita - PLoS One, 2020 - journals.plos.org
Short chain fatty acids (SCFAs) produced endogenously in the gut by bacterial fermentation
of dietary fiber have been studied as nutrients that act as signaling molecules to activate G …

The Impact of H2S on Obesity-Associated Metabolic Disturbances

F Comas, JM Moreno-Navarrete - Antioxidants, 2021 - mdpi.com
Over the last several decades, hydrogen sulfide (H2S) has gained attention as a new
signaling molecule, with extensive physiological and pathophysiological roles in human …

Pannexin 1 and pannexin 3 channels regulate skeletal muscle myoblast proliferation and differentiation

S Langlois, X Xiang, K Young, BJ Cowan… - Journal of Biological …, 2014 - ASBMB
Pannexins constitute a family of three glycoproteins (Panx1,-2, and-3) forming single
membrane channels. Recent work demonstrated that Panx1 is expressed in skeletal muscle …