The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly
established but emerging evidence confirms a pivotal role for mucosal immunity. This review …

Multiple mechanisms of tolerance are induced by oral antigen. Low doses favor active
suppression, whereas higher doses favor clonal anergy/deletion. Oral antigen induces T …

Oral tolerance is classically defined as the suppression of immune responses to antigens
(Ag) that have been administered previously by the oral route. Multiple mechanisms of …

Publisher Summary This chapter discusses the mechanisms and therapeutic applications of
oral tolerance. The most striking characteristic of the gut mucosa is the abundance of the …

IgA Nephropathy (IgAN) is a primary glomerulonephritis problem worldwide that develops
mainly in the 2nd and 3rd decade of life and reaches end-stage kidney disease after 20 …

It is commonly stated that mucosal immunity plays a role in the pathogenesis of IgA
nephropathy (IgAN); however, the search for specific eliciting factors has been largely …

In this paper we concentrate on the role of infections in IgA nephropathy both from a
pathogenetic and clinic point of view. The current hypotheses as regards the role of …

Recent data suggest that gut-associated lymphoid tissue (GALT) plays a major role in the
development of immunoglobulin A (IgA) nephropathy (IgAN). A genome-wide association …

Oral tolerance is the immunologic mechanism by which the mucosal immune system
maintains unresponsiveness to the myriad of antigens in the mucosal environment which …

Immunoglobulin A (IgA) nephropathy is the most common glomerulonephritis worldwide. For
example, in Japan, full-blown IgA nephropathy has been detected in∼ 1.5% of all allograft …