The host response to viral infection includes the induction of type I interferons and the
subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein …

According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …

The recent success of mRNA therapeutics against pathogenic infections has increased
interest in their use for other human diseases including cancer. However, the precise …

Exosomes are vesicles secreted to the extracellular environment through fusion with the
plasma membrane of specific endosomes called multivesicular bodies (MVB) and mediate …

Since the discovery of interferons (IFNs), considerable progress has been made in
describing the nature of the cytokines themselves, the signalling components that direct the …

The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

Following the discovery of protein modification by the small, highly conserved ubiquitin
polypeptide, a number of distinct ubiquitin-like proteins (Ubls) have been found to function …

The 70-kDa heat shock protein (HSP70) family of molecular chaperones represents one of
the most ubiquitous classes of chaperones and is highly conserved in all organisms …

Type I Interferons (IFNs) induce the expression of> 500 genes, which are collectively called
ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon …