The blood–brain barrier (BBB) is a critical regulator of CNS homeostasis. It possesses
physical and biochemical characteristics (ie tight junction protein complexes, transporters) …

Significance: Blood–brain barrier (BBB) disruption is a major pathological change after
intracerebral hemorrhage (ICH) and is both the cause and result of oxidative stress and of …

Disclosures: D. Máthé reported grants from European Union H2020 HCEMM-739593 and
from NRDIO, Hungary, TKP-BIOImaging-2020-4.1. 1-TKP2020 during the conduct of the …

SARS-CoV-2, which causes the Coronavirus Disease 2019 (COVID-19) pandemic, has a
brain neurotropism through binding to the receptor angiotensin-converting enzyme 2 …

Colony-stimulating factor 1 receptor (CSF1R) inhibition has been proposed as a method for
microglia depletion, with the assumption that it does not affect peripheral immune cells …

Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …

The brain is endowed with highly specialized vasculature that is both structurally and
functionally unique compared to vasculature supplying peripheral organs. The blood–brain …

The pathobiology of traumatic and nontraumatic spinal cord injury (SCI), including
degenerative myelopathy, is influenced by neuroinflammation. The neuroinflammatory …

Adequate oxygen supply is essential for the human brain to meet its high energy demands.
Therefore, elaborate molecular and systemic mechanism are in place to enable adaptation …

Neurovascular coupling is a crucial mechanism that matches the high energy demand of the
brain with a supply of energy substrates from the blood. Signaling within the neurovascular …