Subcellular organization of the cAMP signaling pathway
M Zaccolo, A Zerio, MJ Lobo - Pharmacological reviews, 2021 - ASPET
The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …
Molecular changes and signaling events occurring in spermatozoa during epididymal maturation
MG Gervasi, PE Visconti - Andrology, 2017 - Wiley Online Library
After leaving the testis, spermatozoa have not yet acquired the ability to move progressively
and are unable to fertilize oocytes. To become fertilization competent, they must go through …
and are unable to fertilize oocytes. To become fertilization competent, they must go through …
On-demand male contraception via acute inhibition of soluble adenylyl cyclase
M Balbach, T Rossetti, J Ferreira, L Ghanem… - Nature …, 2023 - nature.com
Nearly half of all pregnancies are unintended; thus, existing family planning options are
inadequate. For men, the only choices are condoms and vasectomy, and most current efforts …
inadequate. For men, the only choices are condoms and vasectomy, and most current efforts …
Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development
WG Robichaux III, X Cheng - Physiological reviews, 2018 - journals.physiology.org
This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
Calcium channels in the development, maturation, and function of spermatozoa
A Darszon, T Nishigaki, C Beltran… - Physiological …, 2011 - journals.physiology.org
A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …
New insights into epididymal function in relation to sperm maturation
JL Dacheux, F Dacheux - Reproduction, 2014 - rep.bioscientifica.com
Testicular spermatozoa acquire fertility only after 1 or 2 weeks of transit through the
epididymis. At the end of this several meters long epididymal tubule, the male gamete is …
epididymis. At the end of this several meters long epididymal tubule, the male gamete is …
Control of hyperactivation in sperm
SS Suarez - Human reproduction update, 2008 - academic.oup.com
BACKGROUND Sperm hyperactivation is critical to fertilization, because it is required for
penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from …
penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from …
Major regulatory mechanisms involved in sperm motility
The genetic bases and molecular mechanisms involved in the assembly and function of the
flagellum components as well as in the regulation of the flagellar movement are not fully …
flagellum components as well as in the regulation of the flagellar movement are not fully …
Signaling mechanisms in mammalian sperm motility
MJ Freitas, S Vijayaraghavan… - Biology of …, 2017 - academic.oup.com
The goal of sperm is to fertilize the oocyte. To achieve that purpose, it must acquire motility in
the epididymis and hyperactivated motility in the female reproductive tract. Motility is only …
the epididymis and hyperactivated motility in the female reproductive tract. Motility is only …
Redox regulation of human sperm function: from the physiological control of sperm capacitation to the etiology of infertility and DNA damage in the germ line
Defective sperm function is the largest single defined cause of human infertility and one of
the major reasons we are witnessing an exponential increase in the uptake of assisted …
the major reasons we are witnessing an exponential increase in the uptake of assisted …