The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

After leaving the testis, spermatozoa have not yet acquired the ability to move progressively
and are unable to fertilize oocytes. To become fertilization competent, they must go through …

Nearly half of all pregnancies are unintended; thus, existing family planning options are
inadequate. For men, the only choices are condoms and vasectomy, and most current efforts …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

Testicular spermatozoa acquire fertility only after 1 or 2 weeks of transit through the
epididymis. At the end of this several meters long epididymal tubule, the male gamete is …

BACKGROUND Sperm hyperactivation is critical to fertilization, because it is required for
penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from …

The genetic bases and molecular mechanisms involved in the assembly and function of the
flagellum components as well as in the regulation of the flagellar movement are not fully …

The goal of sperm is to fertilize the oocyte. To achieve that purpose, it must acquire motility in
the epididymis and hyperactivated motility in the female reproductive tract. Motility is only …

Defective sperm function is the largest single defined cause of human infertility and one of
the major reasons we are witnessing an exponential increase in the uptake of assisted …