The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in
antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent …

Most known disease-causing mutations occur in protein-coding regions of DNA. While some
of these involve a loss of protein function (eg, through premature stop codons or missense …

TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate
immune cells encounter different mechanical cues in both health and disease to adapt their …

Neutrophils are the most abundant immune cells in humans and serve as first responders to
a myriad of host perturbations. Equipped with a plethora of antimicrobial molecules …

Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …

Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of
infection, where they fulfill their life-saving antimicrobial functions. While traditionally …

Neutrophils and neutrophil-like cells are the major pathogen-fighting immune cells in
organisms ranging from slime molds to mammals. Central to their function is their ability to …

Neutrophilic polymorphonuclear leukocytes (neutrophils) are highly specialized for their
primary function, the phagocytosis and destruction of microorganisms. When coated with …

Phagocyte-derived reactive oxygen and nitrogen species are of crucial importance for host
resistance to microbial pathogens. Decades of research have provided a detailed …