Inhibitory Smads (I-Smads) have conserved carboxy-terminal MH2 domains but highly
divergent amino-terminal regions when compared with receptor-regulated Smads (R …

This review provides an outline of how our understanding of the neuroendocrine control of
the hypothalamo-pituitary–gonadal axis has evolved since the publication of Geoffrey Harris' …

The epithelial ovarian carcinomas, which make up more than 85% of human ovarian cancer,
arise in the ovarian surface epithelium (OSE). The etiology and early events in the …

Reproductive hormones play a crucial role in the growth and maintenance of the
mammalian skeleton. Indeed, the biological significance for this hormonal regulation of …

Activins and inhibins, structurally related members of the TGF-β superfamily of growth and
differentiation factors, are mutually antagonistic regulators of reproductive and other …

The increase in serum FSH that accompanies female reproductive aging occurs before
changes in estradiol (E2). A decrease in negative feedback from inhibin A (a product of the …

It has been 70 years since the name inhibin was used to describe a gonadal factor that
negatively regulated pituitary hormone secretion. The majority of this period was required to …

The activin and TGF-β type II receptors are members of a separate subfamily of
transmembrane receptors with intrinsic protein kinase activity, which also includes the …

Activin was discovered in the 1980's as a gonadal protein that stimulated FSH release from
pituitary gonadotropes and was thought of as a reproductive hormone. In the ensuing …

Members of the BMP family of signaling molecules display a high conservation of structure
and function, and multiple BMPs are often coexpressed in a variety of tissues during …