Wound care is a major healthcare expenditure. Treatment of burns, surgical and trauma
wounds, diabetic lower limb ulcers and skin wounds is a major medical challenge with …

Tripartite motif (TRIM) family proteins, most of which have E3 ubiquitin ligase activities, have
various functions in cellular processes including intracellular signaling, development …

The NLRP3 inflammasome has a fundamental role in host defence against microbial
pathogens and its deregulation may cause diverse inflammatory diseases. NLRP3 protein …

Abstract Chitosan (CS), a by–product of chitin deacetylation can be useful in a broad range
of purposes, to mention agriculture, pharmaceuticals, material science, food and nutrition …

Antiviral restriction factors are host cellular proteins that constitute a first line of defense
blocking viral replication and propagation. In addition to interfering at critical steps of the …

Endothelial activation plays an essential role in the pathogenesis of sepsis-induced acute
lung injury, however, the detailed regulatory mechanisms remain largely unknown. Here, we …

The last decades of research in innate immunology have revealed a multitude of sensing
receptors that evaluate the presence of microorganisms or cellular damage in tissues. In the …

Tripartite motif (TRIM) proteins constitute one of the largest subfamilies of Really Interesting
New Gene (RING) E3 ubiquitin ligases and contribute to the regulation of numerous cellular …

RNA helicases and E3 ubiquitin ligases mediate many critical functions in cells, but their
actions have largely been studied in distinct biological contexts. Here, we uncover …

Ubiquitination plays a central role in the regulation of various biological functions including
immune responses. Ubiquitination is induced by a cascade of enzymatic reactions by E1 …