miRNAs orchestration of adrenocortical carcinoma-Particular emphasis on diagnosis, progression and drug resistance

WA El-Dakroury, HM Midan, AI Abulsoud… - … -Research and Practice, 2023 - Elsevier
Adrenocortical carcinoma (ACC) is an uncommon aggressive endocrine malignancy that is
nonetheless associated with significant mortality and morbidity rates because of endocrine …

The potential role of miRNAs in the pathogenesis of adrenocortical carcinoma-A focus on signaling pathways interplay

HM Midan, GK Helal, AI Abulsoud, SS Elshaer… - … -Research and Practice, 2023 - Elsevier
Adrenocortical carcinoma (ACC) is a highly malignant infrequent tumor with a dismal
prognosis. microRNAs (miRNAs, miRs) are crucial in post-transcriptional gene expression …

MicroRNA therapeutics in cancer: current advances and challenges

S Reda El Sayed, J Cristante, L Guyon, J Denis… - Cancers, 2021 - mdpi.com
Simple Summary Cancer is a complex disease associated with deregulation of numerous
genes. In addition, redundant cellular pathways limit efficiency of monotarget drugs in …

Integrated genomic characterization of adrenocortical carcinoma

G Assié, E Letouzé, M Fassnacht, A Jouinot… - Nature …, 2014 - nature.com
Adrenocortical carcinomas (ACCs) are aggressive cancers originating in the cortex of the
adrenal gland. Despite overall poor prognosis, ACC outcome is heterogeneous,. We …

Adrenocortical carcinoma: clinical outcomes and prognosis of 330 patients at a tertiary care center

M Ayala-Ramirez, S Jasim, L Feng… - European journal of …, 2013 - academic.oup.com
Objective Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis.
Herein, we describe the clinical features and outcomes for a large series of ACC patients …

Oral squamous cell carcinoma: microRNA expression profiling and integrative analyses for elucidation of tumourigenesis mechanism

M Manikandan, AK Deva Magendhra Rao… - Molecular cancer, 2016 - Springer
Background The advantages and utility of microRNAs (miRNAs) as diagnostic and
prognostic cancer markers is at the vanguard in recent years. In this study, we attempted to …

From diagnosis to resistance: a symphony of miRNAs in pheochromocytoma progression and treatment response

EGE Elsakka, A Elshafei, MA Elkady, AM Yehia… - Naunyn-Schmiedeberg's …, 2024 - Springer
Pheochromocytoma (PCC) is a neuroendocrine tumor that produces and secretes
catecholamine from either the adrenal medulla or extra-adrenal locations. MicroRNAs …

[HTML][HTML] MicroRNA-195-5p suppresses glucose uptake and proliferation of human bladder cancer T24 cells by regulating GLUT3 expression

X Fei, M Qi, B Wu, Y Song, Y Wang, T Li - FEBS letters, 2012 - Elsevier
It has been reported that expression of glucose transporter member 3 (GLUT3) is up-
regulated in bladder cancers. However, the regulating mechanism remains unknown. Here …

Advances in translational research of the rare cancer type adrenocortical carcinoma

C Ghosh, J Hu, E Kebebew - Nature Reviews Cancer, 2023 - nature.com
Adrenocortical carcinoma is a rare malignancy with an annual worldwide incidence of 1–2
cases per 1 million and a 5-year survival rate of< 60%. Although adrenocortical carcinoma is …

Epigenetic silencing of miR-483-3p promotes acquired gefitinib resistance and EMT in EGFR-mutant NSCLC by targeting integrin β3

J Yue, D Lv, C Wang, L Li, Q Zhao, H Chen, L Xu - Oncogene, 2018 - nature.com
All lung cancers patients with epidermal growth factor receptor (EGFR) mutation inevitably
develop acquired resistance to EGFR tyrosine kinase inhibitors (TKI). In up to 30% of cases …