Abstract The Gram-positive bacterium Bacillus subtilis can initiate the process of sporulation
under conditions of nutrient limitation. Here, we review some of the last 5 years of work in …

Chromosomal replication must be limited to once and only once per cell cycle. This is
accomplished by multiple regulatory pathways that govern initiator proteins and replication …

SMC condensin complexes play a central role in compacting and resolving replicated
chromosomes in virtually all organisms, yet how they accomplish this remains elusive. In …

Bacterial proteins often localize to distinct sites within the cell, but the primary cues that
dictate localization are largely unknown. Recent evidence has shown that positive …

From microbes to multicellular eukaryotic organisms, all cells contain pathways responsible
for genome maintenance. DNA replication allows for the faithful duplication of the genome …

The initiation of DNA replication represents a committing step to cell proliferation.
Appropriate replication onset depends on multiprotein complexes that help properly …

Bacterial chromosomes have been found to possess one of two distinct patterns of spatial
organization. In the first, called “ori-ter” and exemplified by Caulobacter crescentus, the …

Coordination of DNA replication with cellular development is a crucial problem in most living
organisms. Bacillus subtilis cells switch from vegetative growth to sporulation when starved …

Initiation of DNA Replication is tightly regulated in all cells since imbalances in chromosomal
copy number are deleterious and often lethal. In bacteria such as Bacillus subtilis and …

How cells maintain their ploidy is relevant to cellular development and disease. Here, we
investigate the mechanism by which the bacterium Bacillus subtilis enforces diploidy as it …