[HTML][HTML] Flavoprotein monooxygenases: versatile biocatalysts

CE Paul, D Eggerichs, AH Westphal, D Tischler… - Biotechnology …, 2021 - Elsevier
Flavoprotein monooxygenases (FPMOs) are single-or two-component enzymes that
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …

Enzyme fusions in biocatalysis: coupling reactions by pairing enzymes

FS Aalbers, MW Fraaije - ChemBioChem, 2019 - Wiley Online Library
One approach to bringing enzymes together for multienzyme biocatalysis is genetic fusion.
This enables the production of multifunctional enzymes that can be used for whole‐cell …

Two-component FAD-dependent monooxygenases: current knowledge and biotechnological opportunities

T Heine, WJH Van Berkel, G Gassner, KH Van Pée… - Biology, 2018 - mdpi.com
Flavoprotein monooxygenases create valuable compounds that are of high interest for the
chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases …

Structural and Mechanistic Studies on Substrate and Stereoselectivity of the Indole Monooxygenase VpIndA1: New Avenues for Biocatalytic Epoxidations and …

J Kratky, D Eggerichs, T Heine… - Angewandte Chemie …, 2023 - Wiley Online Library
Flavoprotein monooxygenases are a versatile group of enzymes for biocatalytic
transformations. Among these, group E monooxygenases (GEMs) catalyze enantioselective …

Native roles of Baeyer–Villiger monooxygenases in the microbial metabolism of natural compounds

C Tolmie, MS Smit, DJ Opperman - Natural product reports, 2019 - pubs.rsc.org
Covering: up to end of June 2018 Baeyer–Villiger monooxygenases (BVMOs) are flavin-
dependent enzymes that catalyse the oxidation of ketones and cyclic ketones to esters and …

Accessing Enantiopure Epoxides and Sulfoxides: Related Flavin‐Dependent Monooxygenases Provide Reversed Enantioselectivity

T Heine, A Scholtissek, S Hofmann, R Koch… - …, 2020 - Wiley Online Library
Enantiopure organic compounds are of major importance for the chemical and
pharmaceutical industry. Flavin‐dependent group E monooxygenases, composed of …

Indigoid dyes by group E monooxygenases: mechanism and biocatalysis

T Heine, C Großmann, S Hofmann, D Tischler - Biological Chemistry, 2019 - degruyter.com
Since ancient times, people have been attracted by dyes and they were a symbol of power.
Some of the oldest dyes are indigo and its derivative Tyrian purple, which were extracted …

[PDF][PDF] Biotechnological methods of sulfoxidation: yesterday, today, tomorrow

W Maczka, K Winska, M Grabarczyk - Catalysts, 2018 - pdfs.semanticscholar.org
The production of chiral sulphoxides is an important part of the chemical industry since they
have been used not only as pharmaceuticals and pesticides, but also as catalysts or …

A new clade of styrene monooxygenases for (R)-selective epoxidation

H Xiao, S Dong, Y Liu, XQ Pei, H Lin… - Catalysis Science & …, 2021 - pubs.rsc.org
Styrene monooxygenases (SMOs) are excellent enzymes for the production of (S)-
enantiopure epoxides, but so far, only one (R)-selective SMO has been identified with a …

Functional characterization of an (R)-selective styrene monooxygenase from streptomyces sp. NRRL S-31

C Cui, C Guo, H Lin, ZY Ding, Y Liu, ZL Wu - Enzyme and Microbial …, 2020 - Elsevier
Styrene monooxygenases (SMOs) are two-component enzymes known to catalyze the
epoxidation of styrene to (S)-styrene oxide. In this work, we identified a new oxygenase …