In a complex system of interrelated reactions, the heart converts chemical energy to
mechanical energy. Energy transfer is achieved through coordinated activation of enzymes …

Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus are all
linked to cardiovascular diseases such as cardiac hypertrophy and heart failure. Diabetic …

Right ventricular (RV) heart failure is the leading cause of death in pulmonary arterial
hypertension (PAH). Peroxisome proliferator–activated receptor γ (PPARγ) acts as a …

Diabetic complications are among the largely exigent health problems currently.
Cardiovascular complications, including diabetic cardiomyopathy (DCM), account for more …

Rationale: Myocardial vulnerability to ischemia/reperfusion (I/R) injury is strictly regulated by
energy substrate metabolism. Branched chain amino acids (BCAA), consisting of valine …

Peroxisome-proliferator-activated receptors (PPARs) comprise three subtypes (PPARα, δ
and γ) to form a nuclear receptor superfamily. PPARs act as key transcriptional regulators of …

Cardiovascular diseases are currently the primary cause of mortality in the whole world.
Growing evidence indicated that the disturbances in cardiac fatty acid metabolism are …

Epicardial adipose tissue (EAT) has morphological and physiological contiguity with the
myocardium and coronary arteries, making it a visceral fat deposit with some unique …

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that
bind to DNA and regulate transcription of genes involved in lipid and glucose metabolism. A …

Honokiol is a key component of a medicinal herb, Magnolia bark. Honokiol possesses
potential pharmacological benefits for many disease conditions, especially cancer. Recent …