Activation of proinflammatory responses in cells of the airway mucosa by particulate matter: oxidant-and non-oxidant-mediated triggering mechanisms

J Øvrevik, M Refsnes, M Låg, JA Holme, PE Schwarze - Biomolecules, 2015 - mdpi.com
Inflammation is considered to play a central role in a diverse range of disease outcomes
associated with exposure to various types of inhalable particulates. The initial mechanisms …

Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

S Halappanavar, S Van Den Brule, P Nymark… - Particle and Fibre …, 2020 - Springer
Toxicity testing and regulation of advanced materials at the nanoscale, ie nanosafety, is
challenged by the growing number of nanomaterials and their property variants requiring …

[HTML][HTML] The role of lysosome in regulated necrosis

A Alu, X Han, X Ma, M Wu, Y Wei, X Wei - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Lysosome is a ubiquitous acidic organelle fundamental for the turnover of unwanted cellular
molecules, particles, and organelles. Currently, the pivotal role of lysosome in regulating cell …

Increased HIF‐1α in Knee Osteoarthritis Aggravate Synovial Fibrosis via Fibroblast‐Like Synoviocyte Pyroptosis

L Zhang, L Zhang, Z Huang, R Xing, X Li… - Oxidative Medicine …, 2019 - Wiley Online Library
Fibroblast‐like synoviocytes (FLSs) are the main effector cells of knee osteoarthritis (KOA)
synovial fibrosis. Our last report showed that NLRP1 and NLRP3 inflammasomes may …

Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)

G Vietti, D Lison, S van den Brule - Particle and fibre toxicology, 2015 - Springer
Several experimental studies have shown that carbon nanotubes (CNT) can induce
respiratory effects, including lung fibrosis. The cellular and molecular events through which …

Advances in mechanisms and signaling pathways of carbon nanotube toxicity

J Dong, Q Ma - Nanotoxicology, 2015 - Taylor & Francis
Carbon nanotubes (CNT) have been developed into new materials with a variety of
industrial and commercial applications. In contrast, the physicochemical properties of CNT at …

[HTML][HTML] Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: antioxidant action of butyrate

X Yuan, L Wang, OM Bhat, H Lohner, PL Li - Redox Biology, 2018 - Elsevier
Short chain fatty acids (SCFAs), a family of gut microbial metabolites, have been reported to
promote preservation of endothelial function and thereby exert anti-atherosclerotic action …

The toxic truth about carbon nanotubes in water purification: a perspective view

R Das, BF Leo, F Murphy - Nanoscale research letters, 2018 - Springer
Without nanosafety guidelines, the long-term sustainability of carbon nanotubes (CNTs) for
water purifications is questionable. Current risk measurements of CNTs are overshadowed …

N6-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-mTOR pathway drove the development of pulmonary fibrosis induced by …

B Han, C Chu, X Su, N Zhang, L Zhou, M Zhang… - …, 2020 - Taylor & Francis
The pulmonary fibrosis could be caused by long-term inhalation of carbon black (CB)
particles. Studies on the mechanisms of pulmonary fibrosis induced by CB are required to …

Reduced pulmonary function and increased pro-inflammatory cytokines in nanoscale carbon black-exposed workers

R Zhang, Y Dai, X Zhang, Y Niu, T Meng, Y Li… - Particle and fibre …, 2014 - Springer
Background Although major concerns exist regarding the potential consequences of human
exposures to nanoscale carbon black (CB) particles, limited human toxicological data is …