Activation of proinflammatory responses in cells of the airway mucosa by particulate matter: oxidant-and non-oxidant-mediated triggering mechanisms
Inflammation is considered to play a central role in a diverse range of disease outcomes
associated with exposure to various types of inhalable particulates. The initial mechanisms …
associated with exposure to various types of inhalable particulates. The initial mechanisms …
Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale
S Halappanavar, S Van Den Brule, P Nymark… - Particle and Fibre …, 2020 - Springer
Toxicity testing and regulation of advanced materials at the nanoscale, ie nanosafety, is
challenged by the growing number of nanomaterials and their property variants requiring …
challenged by the growing number of nanomaterials and their property variants requiring …
[HTML][HTML] The role of lysosome in regulated necrosis
Lysosome is a ubiquitous acidic organelle fundamental for the turnover of unwanted cellular
molecules, particles, and organelles. Currently, the pivotal role of lysosome in regulating cell …
molecules, particles, and organelles. Currently, the pivotal role of lysosome in regulating cell …
Increased HIF‐1α in Knee Osteoarthritis Aggravate Synovial Fibrosis via Fibroblast‐Like Synoviocyte Pyroptosis
L Zhang, L Zhang, Z Huang, R Xing, X Li… - Oxidative Medicine …, 2019 - Wiley Online Library
Fibroblast‐like synoviocytes (FLSs) are the main effector cells of knee osteoarthritis (KOA)
synovial fibrosis. Our last report showed that NLRP1 and NLRP3 inflammasomes may …
synovial fibrosis. Our last report showed that NLRP1 and NLRP3 inflammasomes may …
Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)
G Vietti, D Lison, S van den Brule - Particle and fibre toxicology, 2015 - Springer
Several experimental studies have shown that carbon nanotubes (CNT) can induce
respiratory effects, including lung fibrosis. The cellular and molecular events through which …
respiratory effects, including lung fibrosis. The cellular and molecular events through which …
Advances in mechanisms and signaling pathways of carbon nanotube toxicity
J Dong, Q Ma - Nanotoxicology, 2015 - Taylor & Francis
Carbon nanotubes (CNT) have been developed into new materials with a variety of
industrial and commercial applications. In contrast, the physicochemical properties of CNT at …
industrial and commercial applications. In contrast, the physicochemical properties of CNT at …
[HTML][HTML] Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: antioxidant action of butyrate
Short chain fatty acids (SCFAs), a family of gut microbial metabolites, have been reported to
promote preservation of endothelial function and thereby exert anti-atherosclerotic action …
promote preservation of endothelial function and thereby exert anti-atherosclerotic action …
The toxic truth about carbon nanotubes in water purification: a perspective view
Without nanosafety guidelines, the long-term sustainability of carbon nanotubes (CNTs) for
water purifications is questionable. Current risk measurements of CNTs are overshadowed …
water purifications is questionable. Current risk measurements of CNTs are overshadowed …
N6-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-mTOR pathway drove the development of pulmonary fibrosis induced by …
B Han, C Chu, X Su, N Zhang, L Zhou, M Zhang… - …, 2020 - Taylor & Francis
The pulmonary fibrosis could be caused by long-term inhalation of carbon black (CB)
particles. Studies on the mechanisms of pulmonary fibrosis induced by CB are required to …
particles. Studies on the mechanisms of pulmonary fibrosis induced by CB are required to …
Reduced pulmonary function and increased pro-inflammatory cytokines in nanoscale carbon black-exposed workers
R Zhang, Y Dai, X Zhang, Y Niu, T Meng, Y Li… - Particle and fibre …, 2014 - Springer
Background Although major concerns exist regarding the potential consequences of human
exposures to nanoscale carbon black (CB) particles, limited human toxicological data is …
exposures to nanoscale carbon black (CB) particles, limited human toxicological data is …