Calcium-release channels: structure and function of IP3 receptors and ryanodine receptors
KA Woll, F Van Petegem - Physiological Reviews, 2022 - journals.physiology.org
Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …
Mitochondrial-targeted therapy for doxorubicin-induced cardiotoxicity
Anthracyclines, such as doxorubicin, are effective chemotherapeutic agents for the treatment
of cancer, but their clinical use is associated with severe and potentially life-threatening …
of cancer, but their clinical use is associated with severe and potentially life-threatening …
Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein
Abstract Glucagon-like peptide 1 (GLP-1) is a hormone with essential roles in regulating
insulin secretion, carbohydrate metabolism and appetite. GLP-1 effects are mediated …
insulin secretion, carbohydrate metabolism and appetite. GLP-1 effects are mediated …
Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target
Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …
essential cellular functions, including cardiac and skeletal muscle contraction. The …
The structural basis of ryanodine receptor ion channel function
G Meissner - Journal of General Physiology, 2017 - rupress.org
Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …
Structure and function of IP3 receptors
Inositol 1, 4, 5-trisphosphate receptors (IP3Rs), by releasing Ca2+ from the endoplasmic
reticulum (ER) of animal cells, allow Ca2+ to be redistributed from the ER to the cytosol or …
reticulum (ER) of animal cells, allow Ca2+ to be redistributed from the ER to the cytosol or …
Modulation of cardiac ryanodine receptor 2 by calmodulin
D Gong, X Chi, J Wei, G Zhou, G Huang, L Zhang… - Nature, 2019 - nature.com
The high-conductance intracellular calcium (Ca2+) channel RyR2 is essential for the
coupling of excitation and contraction in cardiac muscle. Among various modulators …
coupling of excitation and contraction in cardiac muscle. Among various modulators …
Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment
Ryanodine receptor type 2 (RyR2) mutations have been linked to an inherited form of
exercise-induced sudden cardiac death called catecholaminergic polymorphic ventricular …
exercise-induced sudden cardiac death called catecholaminergic polymorphic ventricular …
The role of junctophilin proteins in cellular function
SE Lehnart, XHT Wehrens - Physiological reviews, 2022 - journals.physiology.org
Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …
Insights into the pathogenesis of catecholaminergic polymorphic ventricular tachycardia from engineered human heart tissue
Background: Modeling of human arrhythmias with induced pluripotent stem cell–derived
cardiomyocytes has focused on single-cell phenotypes. However, arrhythmias are the …
cardiomyocytes has focused on single-cell phenotypes. However, arrhythmias are the …