Neuroinflammatory process involved in different preclinical models of chemotherapy-induced peripheral neuropathy

G Fumagalli, L Monza, G Cavaletti, R Rigolio… - Frontiers in …, 2021 - frontiersin.org
Peripheral neuropathies are characterized by nerves damage and axonal loss, and they
could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are …

An overview of the cannabinoid type 2 receptor system and its therapeutic potential

B Bie, J Wu, JF Foss, M Naguib - Current Opinion in …, 2018 - journals.lww.com
An overview of the cannabinoid type 2 receptor system and it... : Current Opinion in
Anesthesiology An overview of the cannabinoid type 2 receptor system and its therapeutic …

Comorbidities and risk of chemotherapy-induced peripheral neuropathy among participants 65 years or older in southwest oncology group clinical trials

DL Hershman, C Till, JD Wright, D Awad… - Journal of Clinical …, 2016 - ascopubs.org
Background Neuropathy is a debilitating toxicity associated with various chemotherapy
agents. We evaluated the association between common comorbid conditions and the …

Ruthenium (II)‐Catalyzed Asymmetric Inert C− H Bond Activation Assisted by a Chiral Transient Directing Group

G Li, Q Liu, L Vasamsetty, W Guo… - Angewandte Chemie …, 2020 - Wiley Online Library
A ruthenium (II)‐catalyzed asymmetric intramolecular hydroarylation assisted by a chiral
transient directing group has been developed. A series of 2, 3‐dihydrobenzofurans bearing …

Chronic cannabinoid receptor 2 activation reverses paclitaxel neuropathy without tolerance or cannabinoid receptor 1–dependent withdrawal

L Deng, J Guindon, BL Cornett, A Makriyannis… - Biological …, 2015 - Elsevier
Background Mixed cannabinoid receptor 1 and 2 (CB 1 and CB 2) agonists such as Δ 9-
tetrahydrocannabinol (Δ 9-THC) can produce tolerance, physical withdrawal, and unwanted …

Activation of the CB2 receptor system reverses amyloid-induced memory deficiency

J Wu, B Bie, H Yang, JJ Xu, DL Brown, M Naguib - Neurobiology of aging, 2013 - Elsevier
Cannabinoid type 2 (CB2) agonists are neuroprotective and appear to play modulatory roles
in neurodegenerative processes in Alzheimer's disease. We have studied the effect of 1-((3 …

[HTML][HTML] Chemotherapy-induced peripheral neuropathy: mechanisms and therapeutic avenues

EH Bae, MK Greenwald, AG Schwartz - Neurotherapeutics, 2021 - Elsevier
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious and often persistent
adverse consequence of certain chemotherapeutic agents. It is a major dose-limiting factor …

The endocannabinoidome in neuropsychiatry: Opportunities and potential risks

G Morris, K Walder, S Kloiber, P Amminger… - Pharmacological …, 2021 - Elsevier
The endocannabinoid system (ECS) comprises two cognate endocannabinoid receptors
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …

Cannabinoids in chronic pain: therapeutic potential through microglia modulation

NJ van den Hoogen, EK Harding… - Frontiers in Neural …, 2022 - frontiersin.org
Chronic pain is a complex sensory, cognitive, and emotional experience that imposes a
great personal, psychological, and socioeconomic burden on patients. An estimated 1.5 …

CX3CL1-mediated macrophage activation contributed to paclitaxel-induced DRG neuronal apoptosis and painful peripheral neuropathy

ZZ Huang, D Li, CC Liu, Y Cui, HQ Zhu… - Brain, behavior, and …, 2014 - Elsevier
Painful peripheral neuropathy is a dose-limiting side effect of paclitaxel therapy, which
hampers the optimal clinical management of chemotherapy in cancer patients. Currently the …