Abstract 'T cell exhaustion'is a broad term that has been used to describe the response of T
cells to chronic antigen stimulation, first in the setting of chronic viral infection but more …

Chimeric antigen receptor (CAR) T cells have been approved for use in patients with B cell
malignancies or relapsed and/or refractory multiple myeloma, yet efficacy against most solid …

Most clinically applied cancer immunotherapies rely on the ability of CD8+ cytolytic T cells to
directly recognize and kill tumour cells,–. These strategies are limited by the emergence of …

CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …

Although CD4+ T cell" help" is crucial to sustain antiviral immunity, the mechanisms by
which CD4+ T cells regulate CD8+ T cell differentiation during chronic infection remain …

Tumour-specific CD8 T cell dysfunction is a differentiation state that is distinct from the
functional effector or memory T cell states,,,,–. Here we identify the nuclear factor TOX as a …

Certain bacterial colonists induce a highly specific T cell response. A hallmark of this
encounter is that adaptive immunity develops preemptively, in the absence of an infection …

The efficacy of adoptive T-cell therapies largely depends on the generation of T-cell
populations that provide rapid effector function and long-term protective immunity. Yet it is …

Cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) are a promising
class of immunotherapeutics that activate innate immunity to increase tumour …

Many human cancers are resistant to immunotherapy, for reasons that are poorly
understood. We used a genome-scale CRISPR-Cas9 screen to identify mechanisms of …