Paving the way: contributions of big data to apicomplexan and kinetoplastid research

RS Kent, EM Briggs, BL Colon, C Alvarez… - Frontiers in cellular …, 2022 - frontiersin.org
In the age of big data an important question is how to ensure we make the most out of the
resources we generate. In this review, we discuss the major methods used in Apicomplexan …

Toxoplasma gondii harbors a hypoxia-responsive coproporphyrinogen dehydrogenase-like protein

M Key, CG Baptista, A Bergmann, K Floyd, IJ Blader… - Msphere, 2024 - Am Soc Microbiol
Toxoplasma gondii is an apicomplexan parasite that is the cause of toxoplasmosis, a
potentially lethal disease for immunocompromised individuals. During in vivo infection, the …

Construction of luciferase-expressing Neospora caninum and drug screening

F Wang, Y Xue, Y Pei, M Yin, Z Sun, Z Zhou, J Liu… - Parasites & …, 2024 - Springer
Background Neospora caninum is an apicomplexan parasite that is particularly responsible
for abortions in cattle and neuromuscular disease in dogs. Due to the limited effectiveness of …

Oxadiazon Derivatives Elicit Potent Intracellular Growth Inhibition against Toxoplasma gondii by Disrupting Heme Biosynthesis

KC Rees, Z Dou, DC Whitehead - ACS infectious diseases, 2022 - ACS Publications
Infections of Toxoplasma gondii can cause severe and sometimes fatal diseases in
immunocompromised individuals. The de novo heme biosynthesis pathway is required for …

Safe, Effective, and Inexpensive Clearance of Mycoplasma Contamination from Cultures of Apicomplexan Parasites with Sparfloxacin

DR Malave-Ramos, K Kennedy, MN Key… - Microbiology …, 2022 - Am Soc Microbiol
Most commercial products cannot be used for clearance of Mycoplasma contamination from
cultures of apicomplexan parasites due to the parasites' dependence on the apicoplast, an …