The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical
signaling molecule within eukaryotic cells. Significant progress has been made in clarifying …

With its hallucinations, delusions, thought disorder, and cognitive deficits, schizophrenia
affects the most basic human processes of perception, emotion, and judgment. Evidence …

Schizophrenia, a devastating psychiatric disorder, has a prevalence of 0.5–1%, with high
heritability (80–85%) and complex transmission. Recent studies implicate rare, large, high …

Our understanding of the evolution, formation, and pathological disruption of human brain
circuits is impeded by a lack of comprehensive data on the developing brain transcriptome …

Over the last 20 years, glutamatergic models of schizophrenia have become increasingly
accepted as etiopathological models of schizophrenia, based on the observation that …

Adult neurogenesis occurs throughout life in discrete regions of the adult mammalian brain.
Little is known about the mechanism governing the sequential developmental process that …

Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in
the pathophysiology of schizophrenia,,. Among NRG1 receptors, erbB4 is of particular …

Investigating the neurobiological basis of schizophrenia is a critical step toward establishing
validity of psychiatric diagnoses, predicting outcome, delineating causative mechanisms and …

Abstract Disrupted in Schizophrenia 1 (DISC1) is a schizophrenia risk gene associated with
cognitive deficits in both schizophrenics and the normal ageing population. In this study, we …

This article is the first in a series of seven that will provide an overview of central concepts
and topical issues in modern genetic epidemiology. In this article, we provide an overall …