Role of circRNAs in neurodevelopment and neurodegenerative diseases

J Li, C Sun, H Cui, J Sun, P Zhou - Journal of Molecular Neuroscience, 2021 - Springer
With the rapid development of sequencing technology, scientists have been able to study
and acquire a better understanding of non-coding RNAs (ncRNAs). Circular RNAs …

[HTML][HTML] Epigenetic modulation of opioid receptors by drugs of abuse

KZ Reid, BM Lemezis, TC Hou, R Chen - International Journal of …, 2022 - mdpi.com
Chronic exposure to drugs of abuse produces profound changes in gene expression and
neural activity associated with drug-seeking and taking behavior. Dysregulation of opioid …

[HTML][HTML] Aerobic exercise improves VCI through circRIMS2/miR-186/BDNF-mediated neuronal apoptosis

Y Niu, C Wan, J Zhang, S Zhang, Z Zhao, L Zhu… - Molecular …, 2021 - Springer
Background Vascular cognitive impairment (VCI) is a common cognitive disorder caused by
cerebrovascular disease, ranging from mild cognitive impairment to dementia. Studies have …

[HTML][HTML] Heroin regulates orbitofrontal circular RNAs

G Floris, A Gillespie, MT Zanda, KR Dabrowski… - International Journal of …, 2022 - mdpi.com
The number of drug overdose deaths involving opioids continues to rise in the United States.
Many patients with opioid use disorder (OUD) that seek treatment still experience relapse …

CircTmeff-1 in the nucleus accumbens regulates the reconsolidation of cocaine-associated memory

Q Shen, B Xie, E Galaj, H Yu, X Li, Y Lu, M Zhang… - Brain Research …, 2022 - Elsevier
Reconsolidation of drug memories is the process of restoring unstable memories after
unconditioned (UCS; eg, drugs) or conditioned stimulus (CS; eg, drug-paired contexts), and …

[HTML][HTML] CircSYNDIG1 ameliorates stress-induced abnormal behaviors by suppressing miR-344-5p in mice

X Wang, H Song, Y Du, Y Zhao, Y Fu, Q Meng… - Brain research …, 2023 - Elsevier
Circular RNA (circRNA) plays an important role in diverse stress-related neuropsychiatric
disorders like depression, anxiety and cognitive disorders. Here, using a circRNA …

Orbitofrontal intronic circular RNA from Nrxn3 mediates reward learning and motivation for reward

KR Dabrowski, G Floris, A Gillespie, SE Sillivan - Progress in Neurobiology, 2024 - Elsevier
The orbitofrontal cortex (OFC) is a vital component of brain reward circuitry that is important
for reward seeking behavior. However, OFC-mediated molecular mechanisms underlying …

Comprehensive analysis of differential m6A RNA methylomes in the hippocampus of cocaine-conditioned mice

A Xue, Y Huang, M Li, Q Wei, Q Bu - Molecular Neurobiology, 2021 - Springer
Abstract N6-methyladenosine (m6A) is the most prevalent internal modification found in
mRNAs and lncRNA and plays a vital role in posttranscriptional regulation in mammals. m6A …

[HTML][HTML] Prenatal alcohol exposure results in sex-specific alterations in circular RNA expression in the developing mouse brain

P Paudel, C Pierotti, E Lozano, SK Amoah… - Frontiers in …, 2020 - frontiersin.org
Fetal alcohol spectrum disorders (FASD) are heterogeneous disorders associated with
alcohol exposure to the developing fetus that are characterized by a range of adverse …

[HTML][HTML] Identification of Functional CircRNA–miRNA–mRNA Regulatory Network in Dorsolateral Prefrontal Cortex Neurons of Patients With Cocaine Use Disorder

Y Chen, X Li, S Meng, S Huang, S Chang… - Frontiers in Molecular …, 2022 - frontiersin.org
Increasing evidence has indicated that circular RNAs (circRNAs) act as competing
endogenous RNAs (ceRNAs) regulatory network to regulate the expression of target genes …