Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Dysfunction of lysosomes, the primary hydrolytic organelles in animal cells, is frequently
associated with aging and age‐related diseases. At the cellular level, lysosomal dysfunction …

Abstract Vacuolar protein sorting 35 (VPS35), the core component of the retromer complex
which regulates endosomal trafficking, is genetically linked with Parkinson's disease (PD) …

Maintenance of a pool of active lysosomes with acidic pH and degradative hydrolases is
crucial for cell health. Abnormalities in lysosomal function are closely linked to diseases …

Mutations in the lysosomal membrane protein CLN3 cause Juvenile Neuronal Ceroid
Lipofuscinosis (JNCL). Activation of the lysosomal ion channel TRPML1 has previously …

Juvenile neuronal ceroid lipofuscinosis (or Batten disease) is an autosomal recessive, rare
neurodegenerative disorder that affects mainly children above the age of 5 yr and is most …

A homozygous mutation of the DNAJC6 gene causes autosomal recessive familial type 19
of Parkinson's disease (PARK19). To test the hypothesis that PARK19 DNAJC6 mutations …

Batten disease is characterized by early-onset blindness, juvenile dementia and death
during the second decade of life. The most common genetic causes are mutations in the …

Historically, the clinical manifestations of lysosomal storage diseases offered an early
glimpse into the essential digestive functions of the lysosome. However, it was only recently …

The cation-independent mannose 6-phosphate receptors (CI-M6PR) bind newly
synthesized mannose 6-phosphate (Man-6-P)-tagged enzymes in the Golgi and transport …